Gene: EFR3A
Official Full Name: EFR3 homolog Aprovided by HGNC
Gene Summary: The protein encoded by this gene is part of a complex that plays a role in maintaining an active pool of phosphatidylinositol 4-kinase (PI4K) at the plasma membrane. This protein is thought to be a peripheral membrane protein that associates with the plasma membrane through palmitoylation. Studies indicate that this gene product plays a role in controlling G protein-coupled receptor (GPCR) activity by affecting receptor phosphorylation. Whole exome sequencing studies have implicated mutations in this gene with autism spectrum disorders. [provided by RefSeq, Apr 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29773 | EFR3A Knockout cell line (HeLa) | Human | EFR3A | 1:3~1:6 | Negative | Online Inquiry |
KO29774 | EFR3A Knockout cell line (HCT 116) | Human | EFR3A | 1:2~1:4 | Negative | Online Inquiry |
KO29775 | EFR3A Knockout cell line (HEK293) | Human | EFR3A | 1:3~1:6 | Negative | Online Inquiry |
KO29776 | EFR3A Knockout cell line (A549) | Human | EFR3A | 1:3~1:4 | Negative | Online Inquiry |
EFR3A Gene Knockout Cell Lines represent a robust tool in molecular biology designed to facilitate the study of the EFR3A gene, which is implicated in various cellular processes, including cell signaling and membrane trafficking. By employing CRISPR/Cas9 technology, these cell lines have been genetically engineered to knock out the expression of EFR3A, allowing researchers to investigate the gene's functional roles and its contribution to pathophysiological conditions.
The primary mechanism of action involves the intentional disruption of the gene's coding sequence, resulting in a complete loss of protein expression. This loss enables the examination of cellular phenotypes and pathways that may be altered in the absence of EFR3A, providing vital insights into gene function and its downstream effects. Researchers can utilize these cell lines in various assays, including proliferation, migration, and signaling studies, making them invaluable for elucidating the gene's role in health and disease.
The scientific importance of EFR3A Gene Knockout Cell Lines extends to both research and clinical applications. Characterizing the biological effects of EFR3A loss can yield crucial information relevant to cancer biology, neurobiology, and other areas of medical research, potentially leading to novel therapeutic targets. Furthermore, these knockout models can be employed to screen for drug compounds or treatments that activate or inhibit pathways mediated by EFR3A.
What sets EFR3A Gene Knockout Cell Lines apart from similar products is the precision and reliability of the CRISPR/Cas9 technique used in their development. Traditional gene knockdown methods, such as RNA interference, often yield only transient effects and may not fully eliminate gene function. In contrast, our knockout cell lines ensure a stable and complete disruption of EFR3A, providing more consistent experimental results.
For researchers and clinicians focused on gene function and modulation, EFR3A Gene Knockout Cell Lines offer a significant advantage by providing a solid platform for innovative studies and drug discovery efforts. Utilizing this product allows users to fast-track their research while ensuring accuracy and reproducibility.
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Please note that all services are for research use only. Not intended for any clinical use.
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