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EFNA5 Knockout Cell Lines

Gene: EFNA5

Official Full Name: ephrin A5provided by HGNC

Gene Summary: Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10828 EFNA5 Knockout cell line (HeLa) Human EFNA5 1:3~1:6 Negative Online Inquiry
KO10829 EFNA5 Knockout cell line (HEK293) Human EFNA5 1:3~1:6 Negative Online Inquiry
KO10830 EFNA5 Knockout cell line (A549) Human EFNA5 1:3~1:4 Negative Online Inquiry

Background

EFNA5 Gene Knockout Cell Lines are genetically engineered models specifically designed to study the functional role of the EFNA5 gene, which encodes the ephrin-A5 protein, a significant player in cell signaling and tissue development. By employing CRISPR-Cas9 technology, these cell lines have had the EFNA5 gene selectively inactivated, enabling researchers to explore the biological consequences of its absence in various cellular contexts.

The primary function of these knockout cell lines is to facilitate detailed investigations into the EFNA5 protein's role in processes such as neuronal development, immune response, and tumor biology. Upon inactivation, researchers can observe alterations in cellular behaviors, such as growth patterns, migration, and interaction with other cell types, thereby elucidating the mechanisms through which EFNA5 influences these processes. This insights-driven approach is critical for understanding pathological conditions related to aberrant EFNA5 expression, such as cancer metastasis and neurodevelopmental disorders.

The scientific importance of EFNA5 Gene Knockout Cell Lines extends to both research and clinical applications. In research settings, they serve as invaluable tools for unraveling complex signaling pathways. Clinically, they provide a foundation for the development of targeted therapies that could modulate EFNA5-related pathways. Furthermore, these cell lines offer unique advantages over traditional models, such as more precise genetic manipulation and a reduced risk of off-target effects, thereby enhancing the reliability and reproducibility of experimental results.

Researchers and clinicians benefit from the use of these knockout cell lines as they expedite the understanding of EFNA5's biological relevance, paving the way for potential therapeutic interventions. The ability to utilize a rigorously validated model in genetic studies earns significant value for drug discovery and development, enabling tailored treatments that address specific mechanisms.

At the forefront of biotechnological advancement, our company is dedicated to providing top-tier genetic models and solutions. With a proven track record of innovation and expertise in gene editing technologies, we are committed to supporting the scientific community in their pursuit of discovery and translational research.

Please note that all services are for research use only. Not intended for any clinical use.

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