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EFNA2 Knockout Cell Lines

Gene: EFNA2

Official Full Name: ephrin A2provided by HGNC

Gene Summary: This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10831 EFNA2 Knockout cell line (HCT 116) Human EFNA2 1:2~1:4 Negative Online Inquiry
KO10832 EFNA2 Knockout cell line (HEK293) Human EFNA2 1:3~1:6 Negative Online Inquiry

Background

EFNA2 Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the Ephrin-A2 (EFNA2) gene, a crucial component in various biological processes including cell communication, migration, and tissue patterning. These knockout models are created through targeted gene editing techniques, effectively removing the EFNA2 gene to allow researchers to investigate its functional role in cellular dynamics and to better understand disease mechanisms associated with its dysregulation.

The primary function of EFNA2 Gene Knockout Cell Lines revolves around their ability to mimic the absence of EFNA2 in a controlled environment. This allows scientists to explore the pathways and interactions involved in cellular communication and response to external stimuli without the confounding influences of the EFNA2 signaling pathway. Mechanistically, the knockout model elucidates how the absence of EFNA2 affects processes such as angiogenesis, neuronal development, and inflammatory responses, thus revealing potential therapeutic targets for diseases like cancer and neurodegenerative disorders.

In a research or clinical setting, these cell lines offer significant scientific value by providing insights into EFNA2-related signaling pathways and their implications in various pathologies. They serve as robust platforms for drug discovery, functional assays, and genetic studies, enabling researchers to develop targeted therapies with greater precision. Furthermore, when compared to traditional approaches such as siRNA-mediated knockdown, knockout cell lines offer a more stable and permanent alteration of the gene, providing clearer insights into the long-term effects of gene loss.

The unique selling points of EFNA2 Gene Knockout Cell Lines include their high specificity, reproducibility, and the ability to integrate into existing experimental frameworks with ease. By utilizing these models, researchers are equipped to unravel the complexities of EFNA2's role in health and disease, driving innovation and accelerating the pace of discovery.

At [Your Company Name], we pride ourselves on delivering high-quality research tools tailored to meet the evolving needs of the scientific community, backed by our extensive expertise in genetic engineering and cellular biology. Our commitment to excellence ensures that products like the EFNA2 Gene Knockout Cell Lines empower researchers to unlock the full potential of their studies.

Please note that all services are for research use only. Not intended for any clinical use.

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