Gene: E2F7
Official Full Name: E2F transcription factor 7provided by HGNC
Gene Summary: Enables DNA-binding transcription repressor activity; cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of transcription by RNA polymerase II; and sprouting angiogenesis. Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24102 | E2F7 Knockout cell line (HeLa) | Human | E2F7 | 1:3~1:6 | Negative | Online Inquiry |
KO24103 | E2F7 Knockout cell line (HCT 116) | Human | E2F7 | 1:2~1:4 | Negative | Online Inquiry |
KO24104 | E2F7 Knockout cell line (HEK293) | Human | E2F7 | 1:3~1:6 | Negative | Online Inquiry |
KO24105 | E2F7 Knockout cell line (A549) | Human | E2F7 | 1:3~1:4 | Negative | Online Inquiry |
E2F7 Gene Knockout Cell Lines are cutting-edge biological research tools developed to enable the in-depth study of the E2F7 transcription factor, which plays a significant role in regulating cell cycle progression, differentiation, and apoptosis. By employing CRISPR/Cas9 gene editing technology, these cell lines have been genetically engineered to disrupt the E2F7 gene, allowing researchers to investigate its functional significance and contribute to our understanding of cell cycle regulation and tumorigenesis.
The key function of E2F7 involves its role as a transcriptional repressor or activator, depending on the cellular context. Inhibition of E2F7 has been shown to lead to altered cell cycle dynamics, making the knockout cell lines an invaluable resource for studying pathways associated with cancer progression and response to therapy. Researchers can leverage these cell lines to explore gene interactions, drug efficacy, and the molecular mechanisms underlying various pathologies, thereby contributing to the advancement of personalized medicine.
Compared to conventional cell lines, E2F7 Gene Knockout Cell Lines provide a unique advantage by facilitating more accurate modeling of E2F7-related gene regulatory networks. While other knockout models may be available, the precise gene editing and the comprehensive characterization of these cell lines set them apart, allowing for enhanced reproducibility and validity in scientific findings.
For researchers and clinicians alike, the value of E2F7 Gene Knockout Cell Lines lies in their potential to unveil novel therapeutic targets and refine treatment strategies in oncology. By enabling precise manipulation of E2F7 expression, these cell lines serve as a critical resource for experimental investigation, pushing the boundaries of current cancer research.
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Please note that all services are for research use only. Not intended for any clinical use.
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