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DYNC2H1 Knockout Cell Lines

Gene: DYNC2H1

Official Full Name: dynein cytoplasmic 2 heavy chain 1provided by HGNC

Gene Summary: This gene encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01470 DYNC2H1 Knockout cell line (U-87 MG) Human DYNC2H1 Negative Online Inquiry
KO18121 DYNC2H1 Knockout cell line (HeLa) Human DYNC2H1 1:3~1:6 Negative Online Inquiry
KO18122 DYNC2H1 Knockout cell line (HCT 116) Human DYNC2H1 1:2~1:4 Negative Online Inquiry
KO18123 DYNC2H1 Knockout cell line (HEK293) Human DYNC2H1 1:3~1:6 Negative Online Inquiry
KO18124 DYNC2H1 Knockout cell line (A549) Human DYNC2H1 1:3~1:4 Negative Online Inquiry

Background

DYNC2H1 Gene Knockout Cell Lines are specialized cellular models engineered to lack the DYNC2H1 gene, which encodes a cytoplasmic dynein motor protein crucial for intracellular transport and organelle positioning. By strategically disrupting this gene, researchers can investigate the role of dynein in various cellular processes, including mitosis, cell signaling, and membrane trafficking. The mechanisms facilitated by the DYNC2H1 protein include dynein-mediated retrograde transport along microtubules, emphasizing its significant role in cellular architecture and motility.

The scientific importance of DYNC2H1 Gene Knockout Cell Lines extends to research fields such as neurobiology, cancer biology, and developmental biology, where understanding the implications of cytoskeletal dynamics is pivotal. These knockout models are profoundly valuable in elucidating the molecular pathways affected by dynein dysfunction, providing insights relevant for developing therapeutic strategies for diseases characterized by aberrant intracellular transport, such as neurodegenerative disorders.

What sets DYNC2H1 Gene Knockout Cell Lines apart from traditional cell models is their specificity and precision in targeting the DYNC2H1 gene, allowing for robust studies with clear results that are not confounded by other genetic variations. Additionally, they serve as a control against the background noise present in diverse genetic background studies, further enhancing the validity of experimental findings.

For researchers and clinicians, the value of DYNC2H1 Gene Knockout Cell Lines is underscored by their ability to accelerate the understanding of complex cellular machineries and to validate drug targets in a controlled environment. This product fosters innovative approaches to unraveling the intricacies of human diseases linked to dynein deficiencies.

Our company is dedicated to providing high-quality biological products that empower researchers in their quest for scientific discovery. With a commitment to excellence and innovation, we offer tailored solutions that meet the evolving needs of the scientific community, enabling advancements in both research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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