Gene: DUSP5
Official Full Name: dual specificity phosphatase 5provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10852 | DUSP5 Knockout cell line (HeLa) | Human | DUSP5 | 1:3~1:6 | Negative | Online Inquiry |
KO10853 | DUSP5 Knockout cell line (HCT 116) | Human | DUSP5 | 1:2~1:4 | Negative | Online Inquiry |
KO10854 | DUSP5 Knockout cell line (HEK293) | Human | DUSP5 | 1:3~1:6 | Negative | Online Inquiry |
KO10855 | DUSP5 Knockout cell line (A549) | Human | DUSP5 | 1:3~1:4 | Negative | Online Inquiry |
DUSP5 Gene Knockout Cell Lines are genetically modified cell lines that feature a complete deletion of the dual-specificity protein phosphatase 5 (DUSP5) gene. DUSP5 plays a crucial role in deactivating certain MAP kinases, which are pivotal in regulating a variety of cellular processes including growth, differentiation, and apoptosis. By knocking out this gene, researchers can utilize these cell lines to study the downstream effects on signal transduction pathways and identify potential therapeutic targets in disease models.
The primary functions of DUSP5 Gene Knockout Cell Lines allow scientists to investigate the role of DUSP5 in various biological contexts. These cell lines enable the study of altered cellular responses to stress and inflammatory signals, which can directly inform cancer biology, neurodegenerative diseases, and cardiovascular conditions. The absence of DUSP5 provides a unique platform for assessing kinase signaling dynamics, providing insights that are instrumental in unraveling the complexities of MAPK signaling networks.
The scientific importance of these cell lines is manifold; they facilitate the exploration of the DUSP5 pathway not just from a basic research standpoint but also in translational medicine. These models can aid in drug discovery by pinpointing how disruptions in DUSP5-modulated pathways could lead to specific pathologies. Clinically, they can help in developing new treatment strategies that harness or mitigate MAPK signaling.
What sets DUSP5 Gene Knockout Cell Lines apart from alternative products is their well-characterized genetic modification, ensuring reproducibility and reliability in experimental setups. They are accessible to a wide range of applications due to their adaptability to various cell-based assays, including high-throughput screening, gene expression studies, and platelet function testing, thus making them suitable for diverse research needs.
Investing in DUSP5 Gene Knockout Cell Lines enhances research capabilities by providing robust models that help illuminate critical pathways in human health and disease. Our company prides itself on delivering high-quality biological products supported by cutting-edge technology and an expert team dedicated to advancing life science research.
Please note that all services are for research use only. Not intended for any clinical use.
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