Gene: DUSP14
Official Full Name: dual specificity phosphatase 14provided by HGNC
Gene Summary: Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31250 | DUSP14 Knockout cell line (HeLa) | Human | DUSP14 | 1:3~1:6 | Negative | Online Inquiry |
KO31251 | DUSP14 Knockout cell line (HCT 116) | Human | DUSP14 | 1:2~1:4 | Negative | Online Inquiry |
KO31252 | DUSP14 Knockout cell line (HEK293) | Human | DUSP14 | 1:3~1:6 | Negative | Online Inquiry |
KO31253 | DUSP14 Knockout cell line (A549) | Human | DUSP14 | 1:3~1:4 | Negative | Online Inquiry |
DUSP14 Gene Knockout Cell Lines are sophisticated cellular models designed to facilitate the study of the dual specificity phosphatase 14 (DUSP14) gene, known for its regulatory role in mitogen-activated protein kinase (MAPK) signaling pathways. This product provides researchers with a reliable tool to investigate the physiological and pathological functions of DUSP14, which has implications across various biological processes, including cell proliferation, differentiation, and responses to stress.
The key function of DUSP14 Gene Knockout Cell Lines involves the complete ablation of DUSP14 gene expression, allowing for an in-depth analysis of the resulting changes in MAPK signaling dynamics. By removing the gene, researchers can observe enhanced phosphorylation of MAPK targets, providing insights into how DUSP14 modulates cellular responses in various contexts, including immune responses and cancer biology. This mechanism is particularly beneficial for those studying therapeutic targets in oncology or inflammation.
The scientific importance of DUSP14 Gene Knockout Cell Lines extends to both research and clinical settings, offering a unique platform for investigating how DUSP14 affects tumorigenesis and immune functions. These cell lines can be instrumental in the development of targeted therapies or assessing drug efficacy in conditions where DUSP14 regulation is disrupted.
One of the significant advantages of our DUSP14 Gene Knockout Cell Lines is the precision and reliability achieved through the CRISPR/Cas9 gene editing technology used in their development. Compared to traditional methods of gene knockout, our approach minimizes off-target effects, ensuring high specificity. Additionally, these cell lines are thoroughly validated for consistent performance, providing users with confidence in their experimental results.
For researchers and clinicians, the value of DUSP14 Gene Knockout Cell Lines lies in their ability to serve as powerful experimental models that advance the understanding of complex biological mechanisms, ultimately supporting the quest for innovative therapeutic solutions. Our company prides itself on rigorous scientific expertise and a commitment to providing high-quality biological products that empower scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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