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DUSP1 Knockout Cell Lines

Gene: DUSP1

Official Full Name: dual specificity phosphatase 1provided by HGNC

Gene Summary: The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10874 DUSP1 Knockout cell line (HeLa) Human DUSP1 1:3~1:6 Negative Online Inquiry
KO10875 DUSP1 Knockout cell line (HCT 116) Human DUSP1 1:2~1:4 Negative Online Inquiry
KO10876 DUSP1 Knockout cell line (HEK293) Human DUSP1 1:3~1:6 Negative Online Inquiry
KO10877 DUSP1 Knockout cell line (A549) Human DUSP1 1:3~1:4 Negative Online Inquiry

Background

DUSP1 Gene Knockout Cell Lines are specialized in vitro models created through targeted gene editing techniques, specifically designed to disrupt the dual-specificity phosphatase 1 (DUSP1) gene. This gene plays a critical role in modulating the activity of various mitogen-activated protein kinases (MAPKs), which are involved in cellular signaling pathways that regulate proliferation, differentiation, and apoptosis. The disruption of DUSP1 provides researchers with a powerful tool to investigate the downstream effects of altered MAPK signaling, enabling deeper insights into cellular responses under both normal and pathological conditions.

The DUSP1 Gene Knockout Cell Lines function by selectively silencing the DUSP1 gene, leading to an increase in MAPK activation and a subsequent change in cellular behavior. Researchers can utilize these models to explore mechanisms underlying diverse biological processes, disease progression, and therapeutic responses. The ability to study the physiological roles of DUSP1, especially in cancer, autoimmune diseases, and inflammatory conditions, underscores the significance of these knockout models in translational research.

What sets DUSP1 Gene Knockout Cell Lines apart from other available genetic models is their precision and reliability. Unlike traditional knockout methods, the advanced CRISPR/Cas9 technology used in their development allows for specific and efficient gene editing, minimizing off-target effects. Furthermore, these cell lines come with a comprehensive characterization, ensuring that users can trust in the reproducibility and integrity of their results.

For researchers and clinicians dedicated to advancing knowledge in cell signaling and therapeutic development, DUSP1 Gene Knockout Cell Lines represent an invaluable resource. They facilitate the exploration of complex biological pathways and the testing of novel therapeutic strategies, ultimately contributing to better disease management.

Our company, recognized for its commitment to scientific excellence and innovation, provides these high-quality cell lines along with extensive support to ensure optimal results for your research endeavors. With a focus on delivering reliable and state-of-the-art biological products, we empower scientists to unlock the mysteries of cellular signaling and improve clinical outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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