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DUS2 Knockout Cell Lines

Gene: DUS2

Official Full Name: dihydrouridine synthase 2provided by HGNC

Gene Summary: This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00403 DUS2 gRNA7-gRNA8 KO plasmid DUS2 $850
KO00729 DUS2 Knockout cell line (Hep G2) Human DUS2 1:2~1:4 Negative Online Inquiry
KO18144 DUS2 Knockout cell line (HeLa) Human DUS2 1:3~1:6 Negative Online Inquiry
KO18145 DUS2 Knockout cell line (HCT 116) Human DUS2 1:2~1:4 Negative Online Inquiry
KO18146 DUS2 Knockout cell line (HEK293) Human DUS2 1:3~1:6 Negative Online Inquiry
KO18147 DUS2 Knockout cell line (A549) Human DUS2 1:3~1:4 Negative Online Inquiry

Background

DUS2 Gene Knockout Cell Lines are highly specialized, genetically engineered cell lines designed to facilitate the study of DUS2 gene functions and related biological processes. These cell lines have undergone targeted gene disruption using advanced CRISPR/Cas9 technology, allowing researchers to investigate the implications of DUS2 knockout on cellular activities, metabolic pathways, and disease models.

The core functionalities of DUS2 Gene Knockout Cell Lines lie in their ability to provide insights into the role of the DUS2 gene in RNA processing and nucleotide metabolism. By removing the gene's expression, researchers can observe the resultant phenotypic changes, which contribute to a greater understanding of diseases such as cancer and genetic disorders where aberrations in nucleoside metabolism occur. The use of these cell lines enables precise analysis of the DUS2 gene’s contributions to regulatory networks, ultimately advancing our knowledge of cellular mechanisms and therapeutic targets.

In both research and clinical settings, DUS2 Gene Knockout Cell Lines serve as indispensable tools for validating drug targets, understanding disease mechanisms, and screening potential therapeutic compounds. Their ability to represent a specific genetic alteration in a controlled environment is vital for the elucidation of gene function—allowing for reproducibility and significant insights.

Compared to alternative models, DUS2 Gene Knockout Cell Lines offer enhanced specificity and reduced variability, which are pivotal when analyzing complex biological phenomena. Traditional models may not adequately replicate the nuanced responses seen in vivo, whereas these engineered lines provide a consistent background with defined genetic changes. Additionally, the availability of validated characterization supports confident experimental setups and data reliability.

For researchers and clinicians, the value of DUS2 Gene Knockout Cell Lines is underscored by their capacity to expedite discoveries in gene function and therapeutic interventions. This product is crucial for advancing translational research and developing innovative solutions in pathology.

Our company, with extensive expertise in gene-editing technologies and cellular biology, stands behind the DUS2 Gene Knockout Cell Lines, ensuring that our clientele accesses cutting-edge biological products designed to push the boundaries of modern science and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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