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DUS1L Knockout Cell Lines

Gene: DUS1L

Official Full Name: dihydrouridine synthase 1 likeprovided by HGNC

Gene Summary: Enables tRNA-dihydrouridine16 synthase activity and tRNA-dihydrouridine17 synthase activity. Involved in tRNA dihydrouridine synthesis. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00402 DUS1L gRNA3-gRNA4 KO plasmid DUS1L $850
GP00443 DUS1L gRNA1-gRNA2 KO plasmid DUS1L $850
KO00723 DUS1L Knockout cell line (Hep G2) Human DUS1L 1:2~1:4 Negative Online Inquiry
KO18148 DUS1L Knockout cell line (HeLa) Human DUS1L 1:3~1:6 Negative Online Inquiry
KO18149 DUS1L Knockout cell line (HCT 116) Human DUS1L 1:2~1:4 Negative Online Inquiry
KO18150 DUS1L Knockout cell line (HEK293) Human DUS1L 1:3~1:6 Negative Online Inquiry
KO18151 DUS1L Knockout cell line (A549) Human DUS1L 1:3~1:4 Negative Online Inquiry

Background

DUS1L Gene Knockout Cell Lines are a sophisticated research tool designed to facilitate the study of gene function and the underlying mechanisms of various diseases. These cell lines have been meticulously engineered to have a complete knockout of the DUS1L gene, which encodes a dihydrouridine synthase involved in the biogenesis of modified nucleotides. This targeted knockout provides researchers with a unique opportunity to investigate the gene's role in cellular processes such as RNA metabolism and stress response mechanisms.

The primary function of DUS1L Gene Knockout Cell Lines lies in their ability to eliminate the expression of the DUS1L protein. This disruption allows for detailed analysis of resultant phenotypic changes, enabling researchers to elucidate the biological pathways influenced by DUS1L. The knockout mechanism is based on CRISPR-Cas9 technology, which ensures precise and efficient gene editing, thereby providing high specificity in gene disruption.

In a clinical or research setting, these cell lines have significant implications for understanding pathophysiological processes associated with various diseases, including cancer and metabolic disorders. They enable scientists to conduct drug response assays, study cellular stress responses, and develop novel therapeutic strategies targeting the nuances of DUS1L-related pathways.

What sets our DUS1L Gene Knockout Cell Lines apart from alternatives is our commitment to quality and validation. Each cell line undergoes rigorous characterization, ensuring that researchers receive only the highest quality products, which are essential for reproducible results. Furthermore, the specificity of our knockout services minimizes off-target effects, allowing for clearer interpretations of experimental data.

For researchers and clinicians aiming to explore the intricate workings of gene functions, the DUS1L Gene Knockout Cell Lines represent an invaluable resource that largely contributes to advancing the field of molecular biology and genetics. Our company's expertise in genetic engineering and commitment to innovation ensures that we provide tools that empower scientists in their pursuit of impactful discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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