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DTNB Knockout Cell Lines

Gene: DTNB

Official Full Name: dystrobrevin betaprovided by HGNC

Gene Summary: This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. [provided by RefSeq, Mar 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38154 DTNB Knockout cell line (HeLa) Human DTNB 1:3~1:6 Negative Online Inquiry
KO38155 DTNB Knockout cell line (HCT 116) Human DTNB 1:2~1:4 Negative Online Inquiry
KO38156 DTNB Knockout cell line (HEK293) Human DTNB 1:3~1:6 Negative Online Inquiry
KO38157 DTNB Knockout cell line (A549) Human DTNB 1:3~1:4 Negative Online Inquiry

Background

DTNB Gene Knockout Cell Lines are specialized cellular models in which the DTNB gene has been systematically inactivated or "knocked out," offering a powerful tool for researchers studying gene function and cellular mechanisms. The DTNB gene encodes proteins that are implicated in various biological processes, including redox regulation and signal transduction. By utilizing these knockout cell lines, researchers can dissect the role of DTNB in cellular physiology and pathology, enabling a greater understanding of diseases related to oxidative stress and metabolic dysfunction.

The primary function of DTNB Gene Knockout Cell Lines is to provide a controlled environment for observing the biological consequences of DTNB loss-of-function. This is achieved through the CRISPR/Cas9 gene-editing technology, which allows for precise modifications in the genome. Researchers can use these cell lines to investigate how the absence of DTNB affects cellular pathways, metabolic processes, and the overall homeostasis of the cell, thereby creating a deeper insight into therapeutic targets for diseases such as cancer, neurodegeneration, and metabolic syndromes.

The scientific importance of DTNB Gene Knockout Cell Lines is profound, offering applications in both basic research and clinical settings. In research, they are vital for validating drug targets and exploring gene function within complex biological systems. Clinically, they can serve as platforms for preclinical drug testing and therapeutic modeling, providing crucial information on how therapies may act in the presence or absence of specific genetic factors.

Compared to other gene knockout models, DTNB Gene Knockout Cell Lines stand out due to their enhanced specificity and adaptability. They enable high-throughput screening and can be amenable to various assays, including drug response, metabolic profiling, and mechanistic studies. Additionally, the established stability of these cell lines ensures reproducibility and reliability, which are critical for scientific rigor.

For researchers and clinicians, the value of DTNB Gene Knockout Cell Lines lies in their ability to elucidate gene function and influence therapeutic innovation. The insights gained from these models can lead to breakthroughs in understanding complex disease mechanisms and developing targeted therapies, ultimately improving patient outcomes.

At [Your Company Name], we pride ourselves on our expertise in developing high-quality biological products like the DTNB Gene Knockout Cell Lines. Our commitment to advancing scientific knowledge ensures that researchers have access to the tools they need to push the boundaries of discovery and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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