Gene: DPH7
Official Full Name: diphthamide biosynthesis 7provided by HGNC
Gene Summary: Diphthamide is a post-translationally modified histidine residue present in elongation factor 2, and is the target of diphtheria toxin. This gene encodes a protein that contains a WD-40 domain, and is thought to be involved in diphthamide biosynthesis. A similar protein in yeast functions as a methylesterase, converting methylated diphthine to diphthine, which can then undergo amidation to produce diphthamide. [provided by RefSeq, Oct 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO22645 | DPH7 Knockout cell line (HeLa) | Human | DPH7 | 1:3~1:6 | Negative | Online Inquiry |
KO22646 | DPH7 Knockout cell line (HCT 116) | Human | DPH7 | 1:2~1:4 | Negative | Online Inquiry |
KO22647 | DPH7 Knockout cell line (HEK293) | Human | DPH7 | 1:3~1:6 | Negative | Online Inquiry |
KO22648 | DPH7 Knockout cell line (A549) | Human | DPH7 | 1:3~1:4 | Negative | Online Inquiry |
DPH7 Gene Knockout Cell Lines are engineered cellular models specifically designed to study the implications of the DPH7 gene, which is crucial in the biosynthesis of the lipid modifications in various proteins. This product features genetically modified cells where the DPH7 gene has been disrupted through the CRISPR-Cas9 genome-editing technology, enabling researchers to investigate the functional consequences of DPH7 loss and its role in cellular pathways related to protein glycosylation and signaling.
The key function of DPH7 Gene Knockout Cell Lines lies in their capacity to mimic diseases where DPH7 activity is compromised, providing a controlled environment for studying gene functions, protein interactions, and biochemical processes. Upon deletion of the DPH7 gene, researchers can observe alterations in cell growth, differentiation, and responses to external stimuli, thus allowing for a detailed analysis of the gene’s role in various physiological and pathological contexts.
The scientific importance of these knockout cell lines extends to diverse applications, from fundamental research in molecular biology to potential clinical insights in drug discovery and therapeutic interventions. By studying cellular responses in these engineered cell lines, one can uncover novel targets for drug development and gain a deeper understanding of diseases linked to aberrant protein modifications, such as certain cancers and metabolic disorders.
Compared to traditional parental cell lines, DPH7 Gene Knockout Cell Lines provide a unique advantage due to their precise genetic modification, which eliminates issues of variability and off-target effects commonly associated with chemical inhibitors and transient transfections. This specificity and durability make DPH7 knockout lines superior tools for reproducible research.
For researchers and clinicians focused on cellular mechanisms, biochemical pathways, and innovative therapeutic approaches, these cell lines represent a valuable asset that can accelerate discoveries and enhance experimental rigor. With our extensive expertise in genetic engineering and cellular biology, we are committed to providing high-quality biological products that empower scientists to explore and uncover the complexities of gene function.
Please note that all services are for research use only. Not intended for any clinical use.
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