Gene: DNHD1
Official Full Name: dynein heavy chain domain 1provided by HGNC
Gene Summary: Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in sperm flagellum assembly. Located in sperm flagellum. Implicated in spermatogenic failure 65. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24131 | DNHD1 Knockout cell line (HeLa) | Human | DNHD1 | 1:3~1:6 | Negative | Online Inquiry |
KO24132 | DNHD1 Knockout cell line (HCT 116) | Human | DNHD1 | 1:2~1:4 | Negative | Online Inquiry |
KO24133 | DNHD1 Knockout cell line (HEK293) | Human | DNHD1 | 1:3~1:6 | Negative | Online Inquiry |
KO24134 | DNHD1 Knockout cell line (A549) | Human | DNHD1 | 1:3~1:4 | Negative | Online Inquiry |
DNHD1 Gene Knockout Cell Lines are meticulously developed cellular models designed to facilitate the study of the DNHD1 gene and its associated biological functions. These cell lines have undergone targeted gene editing, specifically CRISPR-Cas9 technology, to achieve a complete knockout of the DNHD1 gene, thus eliminating its expression and allowing researchers to observe the resultant phenotypic changes and molecular pathways in isolation.
The primary function of these knockout cell lines lies in their ability to elucidate the role of DNHD1 in cellular processes such as motility, adhesion, and intracellular transport. By studying these cells, researchers can gain insights into the pathological implications of DNHD1 dysregulation. For instance, alterations in DNHD1 expression have been linked to various cancers and developmental disorders, making these cell lines invaluable for understanding disease mechanisms and potential therapeutic targets.
In a research setting, the DNHD1 Gene Knockout Cell Lines serve as a cornerstone for functional assays, drug screening, and gene interaction studies. Their precise editing enables scientists to generate robust data, paving the way for further explorations into gene function and its influence on cellular behavior. Clinically, these models are pivotal for preclinical testing, providing a reliable foundation for experiments aimed at developing innovative treatments.
Compared to traditional methods of gene knockouts, such as homologous recombination, the CRISPR-based methodology employed in creating these cell lines is significantly more precise and efficient. This results in fewer off-target effects and a more reliable inhibition of gene function, enhancing the integrity of experimental outcomes.
For researchers and clinicians focused on genetic studies and therapeutic development, the DNHD1 Gene Knockout Cell Lines offer a unique and indispensable tool that translates complex genetic insights into practical applications. With our expertise in developing high-quality biological products, we are committed to supporting the scientific community in advancing their research efforts through innovative cell line offerings.
Please note that all services are for research use only. Not intended for any clinical use.
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