Gene: DNA2
Official Full Name: DNA replication helicase/nuclease 2provided by HGNC
Gene Summary: This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38210 | DNA2 Knockout cell line (HeLa) | Human | DNA2 | 1:3~1:6 | Negative | Online Inquiry |
KO38211 | DNA2 Knockout cell line (HCT 116) | Human | DNA2 | 1:2~1:4 | Negative | Online Inquiry |
KO38212 | DNA2 Knockout cell line (HEK293) | Human | DNA2 | 1:3~1:6 | Negative | Online Inquiry |
KO38213 | DNA2 Knockout cell line (A549) | Human | DNA2 | 1:3~1:4 | Negative | Online Inquiry |
DNA2 Gene Knockout Cell Lines are meticulously engineered cellular models that have had the DNA2 gene specifically knocked out, utilizing advanced CRISPR-Cas9 gene editing techniques. The purpose of this product is to facilitate in-depth studies of gene function, regulatory pathways, and genomic stability, making it an indispensable tool for researchers focused on genetics, cell biology, and therapeutic development.
These cell lines primarily function by allowing researchers to investigate the role of the DNA2 gene in various cellular processes, particularly those involved in DNA repair, replication, and maintenance of genomic integrity. By analyzing the phenotypic and molecular changes that occur in the absence of this gene, scientists can elucidate its contributions to cell division and metabolic regulation. This knowledge is crucial for advancing our understanding of diseases such as cancer, where DNA repair mechanisms are often compromised.
The scientific importance of DNA2 Gene Knockout Cell Lines extends to both research and clinical settings. In research, the ability to study the specific effects of DNA2 deficiency can shed light on pathways that may be targeted for therapeutic interventions. Clinically, these cell lines offer potential applications in drug screening and the development of novel cancer therapies, providing a platform to test the efficacy of treatments that target DNA repair mechanisms.
What sets our DNA2 Gene Knockout Cell Lines apart from alternatives is the precision of our gene editing process, which results in cells that exhibit robust and reproducible knockout efficiencies. Additionally, our cell lines have been thoroughly validated for consistent performance across multiple experiments, ensuring that researchers can rely on them for high-quality data.
In conclusion, the DNA2 Gene Knockout Cell Lines represent a significant value for researchers and clinicians seeking to explore the intricacies of gene function and its implications in disease. Our company, with its expertise in genetic engineering and a commitment to providing high-quality biological products, stands ready to support your scientific endeavors with these cutting-edge cellular tools.
Please note that all services are for research use only. Not intended for any clinical use.
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