Gene: DMTN
Official Full Name: dematin actin binding proteinprovided by HGNC
Gene Summary: The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37981 | DMTN Knockout cell line (HeLa) | Human | DMTN | 1:3~1:6 | Negative | Online Inquiry |
KO37982 | DMTN Knockout cell line (HCT 116) | Human | DMTN | 1:2~1:4 | Negative | Online Inquiry |
KO37983 | DMTN Knockout cell line (HEK293) | Human | DMTN | 1:3~1:6 | Negative | Online Inquiry |
KO37984 | DMTN Knockout cell line (A549) | Human | DMTN | 1:3~1:4 | Negative | Online Inquiry |
DMTN Gene Knockout Cell Lines are specialized cell culture models designed to facilitate the in-depth study of gene function and regulation through precise gene editing. These cell lines feature specific genes that have been systematically disrupted, allowing researchers to analyze the phenotypic and biochemical changes resulting from the gene knockout. The underlying mechanism involves the targeted use of cutting-edge CRISPR/Cas9 technology, which ensures high specificity and efficiency in creating knockout mutations. This system allows for the customization of cellular environments conducive to various experimental setups, including drug testing, disease modeling, and gene function analyses.
The scientific importance of DMTN Gene Knockout Cell Lines is underscored by their applications across both basic and applied research domains. In laboratories, they serve as invaluable tools for investigating gene functions, understanding disease mechanisms, and identifying potential therapeutic targets. Clinically, these cell lines can be pivotal in preclinical studies, where they are used to assess drug efficacy and safety profiles, accelerating the development of novel therapies.
One of the significant advantages of DMTN Gene Knockout Cell Lines is their reliability and reproducibility compared to traditional gene knockout methods, which can be labor-intensive and time-consuming. The precision of CRISPR/Cas9 not only minimizes off-target effects but also enhances the speed of generating stable knockout lines, thus providing researchers with more accurate experimental outcomes. Additionally, these cell lines can be characterized and validated with standardized protocols, ensuring consistency across experiments.
For researchers and clinicians, investing in DMTN Gene Knockout Cell Lines translates into gaining access to a powerful toolkit that simplifies complex biological investigations. The versatility of these models means they can be adapted quickly for various studies, making them an essential asset for laboratories aiming to remain at the forefront of molecular biology research.
With an established reputation in developing high-quality biological products, we at DMTN are committed to advancing scientific discovery through our innovative gene knockout technologies. Our expertise ensures that each cell line is thoroughly validated, providing researchers with the confidence needed to explore the intricate world of gene interactions and their implications in health and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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