Gene: DLX3
Official Full Name: distal-less homeobox 3provided by HGNC
Gene Summary: Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38235 | DLX3 Knockout cell line (HeLa) | Human | DLX3 | 1:3~1:6 | Negative | Online Inquiry |
DLX3 Gene Knockout Cell Lines are specifically engineered cellular models that have been designed to silence the DLX3 gene, a transcription factor important in a variety of biological processes, including craniofacial development, neural differentiation, and bone formation. These knockout cell lines serve as invaluable tools for investigating the functional roles of DLX3 in both physiological and pathological contexts, allowing researchers to better understand its mechanisms of action.
The primary function of these cell lines is to provide a controlled environment in which the absence of DLX3 can be studied. Through CRISPR-Cas9 gene editing technology, the gene has been precisely disrupted, enabling researchers to assess alterations in cellular processes such as proliferation, differentiation, and signaling pathways. Such studies can elucidate the impact of DLX3 on key developmental pathways and diseases, including craniofacial dysmorphologies and certain cancers. This makes these cell lines vital in translational research and therapeutic development.
Scientifically, the relevance of DLX3 Gene Knockout Cell Lines extends to both basic and applied research fields. In clinical settings, they can assist in identifying gene-drug interactions, cellular responses to therapies, and novel biomarkers for diseases linked to the DLX3 pathway. Compared to conventional cell models, these knockouts offer enhanced specificity and reproducibility, minimizing confounding variables that could otherwise obscure results.
Moreover, their unique value lies in their ability to enable gene function studies in a range of experimental contexts, making them indispensable for researchers aiming to uncover the complexities of genetic regulation. The cells are also accompanied by optimized protocols and logistic support, solidifying their utility in the lab.
Our company, renowned for its commitment to the development of high-quality biological products, provides not only these innovative cell line solutions but also expertise in gene editing technologies. We empower researchers and clinicians with the necessary tools and knowledge to advance their scientific inquiries and potentially revolutionize therapeutic strategies.
Please note that all services are for research use only. Not intended for any clinical use.
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