Gene: DKK3
Official Full Name: dickkopf WNT signaling pathway inhibitor 3provided by HGNC
Gene Summary: This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09748 | DKK3 Knockout cell line (HeLa) | Human | DKK3 | 1:3~1:6 | Negative | Online Inquiry |
KO09749 | DKK3 Knockout cell line (A549) | Human | DKK3 | 1:3~1:4 | Negative | Online Inquiry |
DKK3 Gene Knockout Cell Lines are genetically engineered cell models designed to study the functional roles of the DKK3 gene, important in various biological processes, including cell signaling, development, and pathogenesis of diseases. By employing CRISPR-Cas9 technology, these cell lines exhibit complete suppression of DKK3 expression, allowing researchers to delve into the consequences of its absence in cellular systems.
The primary function of DKK3 is its role as an antagonist in the Wnt/β-catenin signaling pathway, which is crucial for regulating cell proliferation and differentiation. Disruption of DKK3 can provide insights into its involvement in tumorigenesis, stem cell biology, and tissue regeneration. By utilizing these knockout cell lines, researchers can effectively dissect the signaling mechanisms influenced by DKK3, facilitating a deeper understanding of related diseases, including cancer and degenerative disorders.
The scientific importance of DKK3 Gene Knockout Cell Lines extends into both basic and applied research. In clinical settings, these cell lines can aid in identifying novel therapeutic targets and elucidating biomolecular pathways linked to disease etiology. They are particularly valuable in drug screening processes and development of treatment methods that leverage the dysregulation of this gene.
What sets our DKK3 Gene Knockout Cell Lines apart from alternative models is their high specificity and reproducibility, enabling reliable experimental outcomes that can be directly translated to in vivo studies. Moreover, our cell lines come with comprehensive support, including validated protocols, to ensure researchers can immediately incorporate them into their work.
The value proposition of DKK3 Gene Knockout Cell Lines is clear for researchers and clinicians: by utilizing these cell lines, users can accelerate their studies on gene function and related therapeutic interventions. The high-quality, reliable products offered by our company, backed by our expertise in genetic engineering and cell model development, empowers the scientific community to make breakthroughs in understanding gene regulation and signaling pathways.
Please note that all services are for research use only. Not intended for any clinical use.
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