Gene: DHDH
Official Full Name: dihydrodiol dehydrogenaseprovided by HGNC
Gene Summary: This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01776 | DHDH Knockout cell line (HCT 116) | Human | DHDH | 1:2~1:4 | Negative | Online Inquiry |
KO01777 | DHDH Knockout cell line (HEK293) | Human | DHDH | 1:3~1:6 | Negative | Online Inquiry |
KO01778 | DHDH Knockout cell line (A549) | Human | DHDH | 1:3~1:4 | Negative | Online Inquiry |
DHDH Gene Knockout Cell Lines are specifically engineered cellular models that have had the DHDH gene disrupted, allowing researchers to study the functional implications of this gene in a controlled environment. These cell lines utilize CRISPR/Cas9 technology for high-precision gene editing, enabling reliable elimination of gene expression. By employing these knockout models, scientists can investigate the biochemical pathways affected by the absence of DHDH, leading to insights into metabolic processes, cellular response to stress, and potential therapeutic targets involved in various diseases.
The primary function of the DHDH knockout involves its role in understanding its pathway in the biosynthesis of certain metabolic compounds. DHDH (dihydrodiol dehydrogenase) is known to influence important catabolic reactions and the metabolism of specific xenobiotics. By harnessing the knockout model, researchers can elucidate how the DHDH gene affects cellular behaviors, such as proliferation, differentiation, and apoptosis, thus offering a valuable resource for drug development and toxicology studies.
From a scientific standpoint, these knockout cell lines have vast applications in both research and clinical settings. They are particularly useful for modeling diseases where DHDH is implicated, such as liver dysfunction and drug metabolism disorders, offering insights that can pave the way for novel therapies. Additionally, understanding the DHDH knockout can inform research in pharmacogenomics, where the metabolic differences influenced by such genes can affect drug efficacy and safety.
What sets DHDH Gene Knockout Cell Lines apart from traditional gene knockout models is their enhanced reliability, minimal off-target effects, and robust integration of safety mechanisms. Researchers can trust these cell lines for reproducible results and consistent gene expression profiles, ensuring that investigations yield meaningful data with high translational potential.
Ultimately, the DHDH Gene Knockout Cell Lines are invaluable tools for researchers and clinicians looking to deepen their understanding of gene function and its implications in health and disease. Our company, known for its cutting-edge gene editing technologies and commitment to advancing biological research, stands behind these products, ensuring they meet the highest standards of quality and efficacy. With our expertise and dedication to innovation, we provide researchers with the resources they need to uncover new scientific insights.
Please note that all services are for research use only. Not intended for any clinical use.
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