Gene: DGKG
Official Full Name: diacylglycerol kinase gammaprovided by HGNC
Gene Summary: This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07766 | DGKG Knockout cell line (HCT 116) | Human | DGKG | 1:2~1:4 | Negative | Online Inquiry |
KO07767 | DGKG Knockout cell line (A549) | Human | DGKG | 1:3~1:4 | Negative | Online Inquiry |
DGKG Gene Knockout Cell Lines are sophisticated and invaluable biological tools designed to facilitate the study of the diacylglycerol kinase (DGK) gene and its associated pathways. These cell lines have been genetically modified to disrupt the function of the DGKG gene, allowing for the observation of cellular behavior and molecular interactions in the absence of DGK activity. By providing a model to study the resultant physiological changes, researchers can gain critical insights into the roles that DGK plays in various biological processes, including signal transduction and lipid metabolism.
The key function of DGKG knockout cell lines is to enable researchers to explore the impact of DGK deficiency on cellular signaling pathways, particularly those involving diacylglycerol (DAG) and its downstream effector pathways. The mechanisms by which these knockout lines operate reveal how the deregulation of DGK can contribute to a range of pathological conditions, such as cancer, cardiovascular disease, and neurological disorders. By using these models, researchers can elucidate the molecular mechanisms underlying these diseases, paving the way for novel therapeutic strategies.
In terms of scientific importance, DGKG knockout cell lines represent a significant advancement in the toolkit available for both basic and translational research. Their applications extend to investigating the pharmacological effects of new compounds targeting DGK pathways, providing a platform for drug discovery and development. Furthermore, they can be utilized to uncover gene-environment interactions relevant to various pathophysiological conditions.
The unique selling point of our DGKG Gene Knockout Cell Lines over alternatives lies in their precision and reliability. Our cell lines are confirmed through rigorous validation techniques, ensuring that they exhibit stable knockout characteristics and consistent phenotypic responses. Researchers benefit from using our products because they facilitate reproducible experiments and ultimately enhance the reliability of data generated in both academic and industrial settings.
Investing in DGKG Gene Knockout Cell Lines means obtaining a high-quality product that stands at the frontier of molecular research, enabling vital discoveries that could lead to breakthrough innovations in healthcare. Our company, renowned for its expertise in developing cutting-edge biological solutions, is committed to empowering researchers and clinicians with the resources they need to advance their work and push the boundaries of scientific knowledge.
Please note that all services are for research use only. Not intended for any clinical use.
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