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DGKE Knockout Cell Lines

Gene: DGKE

Official Full Name: diacylglycerol kinase epsilonprovided by HGNC

Gene Summary: Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07772 DGKE Knockout cell line (HeLa) Human DGKE 1:3~1:6 Negative Online Inquiry
KO07773 DGKE Knockout cell line (HCT 116) Human DGKE 1:2~1:4 Negative Online Inquiry
KO07774 DGKE Knockout cell line (HEK293) Human DGKE 1:3~1:6 Negative Online Inquiry
KO07775 DGKE Knockout cell line (A549) Human DGKE 1:3~1:4 Negative Online Inquiry

Background

DGKE Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to facilitate research focused on the diacylglycerol kinase epsilon (DGKE) gene. These cell lines are created through precise gene-editing techniques, such as CRISPR/Cas9, effectively eliminating the DGKE gene's function. This knockout approach allows researchers to study the physiological and pathological roles of DGKE in various biological contexts, including neuronal function and immune response.

The key mechanism of these cell lines involves the disruption of the DGKE gene, which is implicated in key metabolic pathways involving lipid signaling and inflammation. By studying these cell lines, researchers can observe the resultant phenotypic changes, such as altered cellular signaling pathways, modifications in cell proliferation, and shifts in gene expression profiles, providing vital insights into the gene's role in cell biology.

The scientific importance of DGKE Gene Knockout Cell Lines cannot be overstated. They are invaluable tools for exploring the gene's involvement in disease models, particularly in neurodegeneration and immune disorders. In clinical settings, understanding DGKE's function may lead to novel therapeutic strategies for managing relevant diseases, enhancing our overall understanding of cellular metabolism and signaling.

What sets DGKE Gene Knockout Cell Lines apart from alternatives is their specificity and reliability. By utilizing validated gene knockout techniques, our cell lines offer consistent results across experiments, reducing variability and ensuring reproducibility. Additionally, these cell lines are accompanied by comprehensive characterizations, providing researchers with essential data to support their findings.

For researchers and clinicians alike, investing in DGKE Gene Knockout Cell Lines is a strategic move towards advancing understanding in molecular biology and therapeutic development. With our commitment to high-quality biological products and collaborative support, our company stands out as a trusted partner in scientific discovery, ensuring that you have access to the tools needed for groundbreaking research.

Please note that all services are for research use only. Not intended for any clinical use.

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