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DGCR2 Knockout Cell Lines

Gene: DGCR2

Official Full Name: DiGeorge syndrome critical region gene 2provided by HGNC

Gene Summary: Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32402 DGCR2 Knockout cell line (HeLa) Human DGCR2 1:3~1:6 Negative Online Inquiry
KO32403 DGCR2 Knockout cell line (HCT 116) Human DGCR2 1:2~1:4 Negative Online Inquiry
KO32404 DGCR2 Knockout cell line (HEK293) Human DGCR2 1:3~1:6 Negative Online Inquiry
KO32405 DGCR2 Knockout cell line (A549) Human DGCR2 1:3~1:4 Negative Online Inquiry

Background

DGCR2 Gene Knockout Cell Lines are precisely engineered cellular models where the DGCR2 gene has been systematically disrupted, creating a valuable tool for the investigation of gene function and disease mechanisms. The DGCR2 gene is associated with the development of several health conditions, making its knockout model essential for studying gene regulation, cell signaling pathways, and developmental biology.

These cell lines utilize CRISPR-Cas9 technology for the targeted knockout of the DGCR2 gene, ensuring a high degree of specificity and efficiency. Through this mechanism, researchers can observe changes in cellular phenotype, gene expression, and signaling pathways that are initiated by the absence of DGCR2 expression. This enables enhanced insights into the pathways that contribute to diseases associated with this gene, including congenital heart disease and other developmental disorders.

The scientific importance of DGCR2 Gene Knockout Cell Lines extends to both research and clinical applications. They serve as crucial models for drug screening, genetic studies, and the development of therapeutic strategies aimed at diseases linked to the DGCR2 gene. With their ability to replicate human disease states in vitro, these models facilitate the testing of hypotheses regarding gene function and interaction in a controlled environment.

In comparison to traditional knockout methods, which may involve time-consuming processes and large-scale animal models, DGCR2 Gene Knockout Cell Lines offer a fast and ethical alternative for researchers. They provide a consistent and reproducible platform for experiments, enabling a quicker transition from discovery to application without the ethical and logistical challenges associated with animal studies.

Researchers and clinicians can greatly benefit from the availability of these cell lines, as they embody a cutting-edge approach to understanding complex genetic interactions and developing innovative treatments. By allowing for manipulation of the DGCR2 pathway, these models empower scientists to unlock new knowledge and potential therapeutic avenues.

Our company specializes in the development of state-of-the-art genetic models, including DGCR2 Gene Knockout Cell Lines, backed by extensive expertise in molecular biology and genomic editing technologies. We are committed to supporting the scientific community by providing high-quality products that enhance the research landscape and foster groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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