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DEPDC5 Knockout Cell Lines

Gene: DEPDC5

Official Full Name: DEP domain containing 5, GATOR1 subcomplex subunitprovided by HGNC

Gene Summary: This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09181 DEPDC5 Knockout cell line (HeLa) Human DEPDC5 1:3~1:6 Negative Online Inquiry
KO09182 DEPDC5 Knockout cell line (HCT 116) Human DEPDC5 1:2~1:4 Negative Online Inquiry
KO09183 DEPDC5 Knockout cell line (HEK293) Human DEPDC5 1:3~1:6 Negative Online Inquiry
KO09184 DEPDC5 Knockout cell line (A549) Human DEPDC5 1:3~1:4 Negative Online Inquiry

Background

DEPDC5 Gene Knockout Cell Lines represent a groundbreaking tool in cellular and molecular biology, offering researchers a powerful means to investigate the role of the DEPDC5 gene in cellular processes. The DEPDC5 gene plays a crucial role in the regulation of the mTOR signaling pathway, which is essential for cellular growth, metabolism, and proliferation. By employing advanced CRISPR-Cas9 technology, our cell lines have been precisely engineered to disrupt the DEPDC5 gene, enabling the study of its specific contributions to various physiological and pathological conditions.

These knockout cell lines function by removing the gene's coding sequence, leading to the loss of DEPDC5 protein expression, which subsequently alters mTOR pathway activity. This dissection of signaling pathways is invaluable for understanding mechanisms related to cancer, metabolic disorders, and neurodevelopmental diseases. Researchers can utilize these cell lines to explore the effects of DEPDC5 loss on cellular behavior, offering insights that may lead to novel therapeutic strategies.

Scientific applications extend from fundamental research to translational medicine, making this product invaluable in both academic and clinical settings. By integrating DEPDC5 knockout models into experimental frameworks, scientists can better elucidate the gene’s role and influence in disease models, thus driving forward the field of personalized medicine.

Our DEPDC5 Gene Knockout Cell Lines offer unparalleled specificity and reliability compared to conventional models, which may produce variable results due to incomplete gene editing or off-target effects. The superior fidelity of our cell lines not only enhances data validity but also accelerates research timelines, enabling more efficient exploration of therapeutic avenues.

In choosing our DEPDC5 Gene Knockout Cell Lines, researchers and clinicians can leverage our extensive expertise in genetic engineering and cellular development. With a commitment to high-quality biological products, we empower the scientific community to push the boundaries of discovery and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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