Gene: DENND1C
Official Full Name: DENN domain containing 1Cprovided by HGNC
Gene Summary: The protein encoded by this gene functions as a guanine nucleotide exchange factor for the early endosomal small GTPase RAB35, which regulates endosomal membrane trafficking and is involved in actin polymerization. The encoded protein activates RAB35 by promoting the exchange of RAB35-bound GDP for GTP. This gene may play a role in linking RAB35 activation with the clathrin machinery. [provided by RefSeq, May 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18334 | DENND1C Knockout cell line (HCT 116) | Human | DENND1C | 1:2~1:4 | Negative | Online Inquiry |
KO18335 | DENND1C Knockout cell line (A549) | Human | DENND1C | 1:3~1:4 | Negative | Online Inquiry |
DENND1C Gene Knockout Cell Lines are specialized biological models that have been engineered to lack functional DENND1C gene expression. These knockout cell lines are essential tools in molecular biology and genetics, providing researchers with the capability to study the specific role of DENND1C in cellular processes and disease mechanisms. The DENND1C gene is implicated in various cellular functions, including endosomal transport and signaling pathways, which makes these knockout models invaluable for understanding its contributions to health and disease.
The primary function of DENND1C Gene Knockout Cell Lines is to facilitate the investigation of gene function through loss-of-function studies. By using CRISPR/Cas9 technology, these cell lines exhibit complete abrogation of DENND1C protein activity, allowing researchers to delineate the gene's role in cellular proliferation, apoptosis, and receptor signaling. This specificity enables targeted studies that can reveal critical pathways affected by DENND1C absence, thereby providing insights into various pathological conditions such as cancer and genetic disorders.
In research and clinical settings, these knockout cell lines play a crucial role in screening for potential therapeutic targets, validating drug efficacy, and understanding patient-specific responses in translational medicine. The ability to manipulate gene expression in these models allows for a more accurate representation of human disease states, which is essential for the development of novel interventions.
Compared to traditional cell lines, the DENND1C Gene Knockout Cell Lines offer several key advantages, including precise gene editing, reproducibility, and the ability to generate data that is directly translatable to human conditions. This specificity not only enhances the reliability of experimental results but also accelerates the research process by providing a clearer understanding of gene-functional interplay.
For researchers and clinicians, the value of DENND1C Gene Knockout Cell Lines lies in their capacity to uncover essential biological mechanisms and advance therapy development, ensuring the alignment of experimental models with clinical relevance. Our company is dedicated to providing high-quality research tools with a strong emphasis on the latest advancements in gene editing technology, equipping scientists with the resources they need to drive innovation in biological research.
Please note that all services are for research use only. Not intended for any clinical use.
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