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DENND1B Knockout Cell Lines

Gene: DENND1B

Official Full Name: DENN domain containing 1Bprovided by HGNC

Gene Summary: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18336 DENND1B Knockout cell line (HeLa) Human DENND1B 1:3~1:6 Negative Online Inquiry
KO18337 DENND1B Knockout cell line (HCT 116) Human DENND1B 1:2~1:4 Negative Online Inquiry
KO18338 DENND1B Knockout cell line (HEK293) Human DENND1B 1:3~1:6 Negative Online Inquiry
KO18339 DENND1B Knockout cell line (A549) Human DENND1B 1:3~1:4 Negative Online Inquiry

Background

DENND1B Gene Knockout Cell Lines are genetically engineered cell lines designed to facilitate the study of the DENND1B gene, which encodes a member of the DENN (differentially expressed in normal and neoplastic cells) family of proteins involved in cellular signaling and membrane trafficking. This product represents a critical resource for researchers aiming to elucidate the biological roles of DENND1B in various cellular processes, including cytokinesis and intracellular vesicle transport.

These knockout cell lines are developed through sophisticated CRISPR/Cas9 gene editing technology, effectively creating a loss-of-function model that allows for the investigation of phenotypic changes associated with DENND1B deficiency. By removing the coding sequences of the DENND1B gene, researchers can utilize these cell lines to explore its contribution to tumorigenesis, cell cycle regulation, and other pathophysiological conditions. Such functional insights are invaluable for the advancement of targeted therapies and novel treatment modalities.

The scientific importance of DENND1B Gene Knockout Cell Lines extends to diverse research applications, including cancer biology, neurobiology, and metabolic studies, where understanding the underlying genetic and molecular mechanisms is crucial. Compared to traditional models, these knockout cell lines offer distinct advantages such as specificity, reproducibility, and the ability to efficiently assess gene function in a controlled environment.

For researchers and clinicians, the value of these cell lines lies in their potential to accelerate discoveries related to gene function and disease mechanisms, ultimately paving the way for innovative biological interventions. Furthermore, our company brings extensive expertise in genetic engineering and cell line development, ensuring high-quality products that meet the rigorous standards of today's research landscape. By choosing our DENND1B Gene Knockout Cell Lines, users are equipping themselves with a powerful tool to advance their scientific inquiries and contribute to groundbreaking advancements in biology and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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