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DDX1 Knockout Cell Lines

Gene: DDX1

Official Full Name: DEAD-box helicase 1provided by HGNC

Gene Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that acts as an ATP-dependent RNA helicase that has been found to promote coronaviruses replication. [provided by RefSeq, Aug 2021]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02332 DDX1 Knockout cell line (HeLa) Human DDX1 1:3~1:6 Negative Online Inquiry
KO02333 DDX1 Knockout cell line (HCT 116) Human DDX1 1:2~1:4 Negative Online Inquiry
KO02334 DDX1 Knockout cell line (HEK293) Human DDX1 1:3~1:6 Negative Online Inquiry

Background

DDX1 Gene Knockout Cell Lines are a powerful tool designed for researchers aiming to elucidate the functional role of the DDX1 gene, which encodes a highly conserved DEAD-box RNA helicase involved in various cellular processes, including RNA processing, translation regulation, and stress response. These knockout cell lines are engineered through CRISPR-Cas9 technology, enabling the precise disruption of the DDX1 gene, thus facilitating studies on the implications of DDX1 loss in cellular homeostasis and gene expression regulation.

The key function of DDX1 is its involvement in RNA metabolism, particularly in unwinding RNA structures that need to be translated or processed. By eliminating this gene's expression in our cell line models, researchers can investigate the downstream effects on protein synthesis and mRNA stability, thereby contributing to a deeper understanding of fundamental biological processes as well as disease mechanisms, especially in cancer and neurodegenerative disorders. These applications demonstrate not only the relevance of DDX1 in essential biological pathways but also its potential as a target for therapeutic interventions.

What sets our DDX1 Gene Knockout Cell Lines apart from alternative products is their rigorous validation, ensuring a complete and functional knockout verified by sequencing and phenotypic analyses. Researchers benefit from our user-friendly protocols, which streamline their experimental workflow while maintaining high specificity and reproducibility. The availability of multiple cell types—ranging from human to mouse models—also offers versatility in experimental design suited to diverse research contexts.

Moreover, our DDX1 Gene Knockout Cell Lines provide unmatched support for hypothesis-driven research, allowing scientists to generate robust data that can lead to novel discoveries in gene function and therapeutic strategies. By choosing our product, researchers align with a commitment to quality and innovation that has become the hallmark of our company, renowned for its expertise in providing cutting-edge biological products tailored to advance scientific exploration and clinical research.

Please note that all services are for research use only. Not intended for any clinical use.

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