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DDHD1 Knockout Cell Lines

Gene: DDHD1

Official Full Name: DDHD domain containing 1provided by HGNC

Gene Summary: This gene is a member of the intracellular phospholipase A1 gene family. The protein encoded by this gene preferentially hydrolyzes phosphatidic acid. It is a cytosolic protein with some mitochondrial localization, and is thought to be involved in the regulation of mitochondrial dynamics. Overexpression of this gene causes fragmentation of the tubular structures in mitochondria, while depletion of the gene results in mitochondrial tubule elongation. Deletion of this gene in male mice caused fertility defects, resulting from disruption in the organization of the mitochondria during spermiogenesis. In humans, mutations in this gene have been associated with hereditary spastic paraplegia (HSP), also known as Strumpell-Lorrain disease, or, familial spastic paraparesis (FSP). This inherited disorder is characterized by progressive weakness and spasticity of the legs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25876 DDHD1 Knockout cell line (HeLa) Human DDHD1 1:3~1:6 Negative Online Inquiry
KO25877 DDHD1 Knockout cell line (HCT 116) Human DDHD1 1:2~1:4 Negative Online Inquiry
KO25878 DDHD1 Knockout cell line (HEK293) Human DDHD1 1:3~1:6 Negative Online Inquiry
KO25879 DDHD1 Knockout cell line (A549) Human DDHD1 1:3~1:4 Negative Online Inquiry

Background

DDHD1 Gene Knockout Cell Lines are a robust research tool designed to investigate the biological roles of the DDHD1 gene, which plays a critical role in lipid metabolism and cellular signaling pathways. By utilizing targeted gene-editing technologies such as CRISPR/Cas9, these cell lines demonstrate a complete knockout of the DDHD1 gene, enabling researchers to analyze the downstream effects of its absence on cellular function and disease models.

These knockout cell lines operate by providing a controlled environment in which the elimination of DDHD1 allows for the study of its associated biological pathways and the investigation of potential ramifications in metabolic disorders, neurodegenerative diseases, and cancer. The absence of this gene helps to elucidate the mechanistic underpinnings of lipid droplet dynamics and the normal physiological roles of the gene in cellular contexts, crucial for developing therapeutic strategies.

In scientific research and clinical settings, DDHD1 Gene Knockout Cell Lines serve as an invaluable asset, particularly for studies focused on lipid signaling, cellular homeostasis, and the pathogenesis of conditions related to aberrant DDHD1 function. Their unique capabilities allow for more accurate modeling of diseases and drug testing compared to standard cell lines, making them indispensable for translational applications.

One of the key advantages of our DDHD1 Gene Knockout Cell Lines compared to alternative products on the market is their high efficiency and specificity, ensuring minimal off-target effects while maintaining cellular viability. This provides a clear advantage for obtaining reliable data in experimental setups, facilitating reproducibility and validation in subsequent studies.

For researchers and clinicians, these knockout cell lines represent not only a powerful experimental tool but also a pathway to unlock new insights into complex biological processes. By integrating these lines into research, users can significantly advance their understanding of lipid metabolism and its implications in human health.

Backed by our company’s extensive expertise in genetic manipulation technologies and commitment to providing high-quality biological products, we offer a portfolio that empowers scientists to push the boundaries of discovery and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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