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DCLRE1C Knockout Cell Lines

Gene: DCLRE1C

Official Full Name: DNA cross-link repair 1Cprovided by HGNC

Gene Summary: This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18375 DCLRE1C Knockout cell line (HeLa) Human DCLRE1C 1:3~1:6 Negative Online Inquiry
KO18376 DCLRE1C Knockout cell line (HCT 116) Human DCLRE1C 1:2~1:4 Negative Online Inquiry
KO18377 DCLRE1C Knockout cell line (HEK293) Human DCLRE1C 1:3~1:6 Negative Online Inquiry
KO18378 DCLRE1C Knockout cell line (A549) Human DCLRE1C 1:3~1:4 Negative Online Inquiry

Background

DCLRE1C Gene Knockout Cell Lines are specialized cell models created through advanced genetic engineering techniques to disrupt the DCLRE1C gene, which encodes a critical protein involved in DNA repair processes. This precise knockout technique is accomplished using CRISPR/Cas9 technology, allowing for targeted editing of the genome and enabling researchers to study the functional consequences of DCLRE1C loss of function in a controlled environment.

These cell lines serve as invaluable tools for elucidating the role of DCLRE1C in cellular repair mechanisms and its implications in various diseases, including immunodeficiencies associated with DNA repair deficiencies. By simulating the genetic conditions related to human pathologies, such as severe combined immunodeficiency, scientists can investigate the molecular pathways through which DCLRE1C influences cellular responses to DNA damage, leading to potential therapeutic targets.

The scientific importance of DCLRE1C Gene Knockout Cell Lines extends to their applications in drug discovery and the assessment of gene therapy approaches. Researchers can utilize these models to screen for compounds that may restore normal function or mitigate the effects of DCLRE1C deficiencies, paving the way for novel treatment strategies.

Compared to traditional cell lines, the unique selling point of DCLRE1C Gene Knockout Cell Lines lies in their specificity and ability to mimic pathophysiological states more accurately. Other alternatives may lack the precision required for discerning the nuanced cellular behaviors and interactions resulting from gene ablation.

For researchers and clinicians, the value of utilizing these cell lines is paramount, as they provide a sophisticated platform for understanding complex biological processes, thus contributing to advancements in genetic research and therapeutic development.

Our company specializes in cutting-edge genetic engineering solutions, offering products that empower scientific inquiry and innovation. We are committed to supporting the research community with high-quality, tailored cell lines that enhance experimental outcomes and foster breakthroughs in understanding genetic diseases.

Please note that all services are for research use only. Not intended for any clinical use.

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