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DCAF13 Knockout Cell Lines

Gene: DCAF13

Official Full Name: DDB1 and CUL4 associated factor 13provided by HGNC

Gene Summary: Enables nuclear estrogen receptor binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including decidualization; epigenetic programming in the zygotic pronuclei; and spindle assembly involved in female meiosis. Located in several cellular components, including centrosome; cytosol; and nuclear lumen. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28691 DCAF13 Knockout cell line (HeLa) Human DCAF13 1:3~1:6 Negative Online Inquiry
KO28692 DCAF13 Knockout cell line (HCT 116) Human DCAF13 1:2~1:4 Negative Online Inquiry
KO28693 DCAF13 Knockout cell line (HEK293) Human DCAF13 1:3~1:6 Negative Online Inquiry
KO28694 DCAF13 Knockout cell line (A549) Human DCAF13 1:3~1:4 Negative Online Inquiry

Background

DCAF13 Gene Knockout Cell Lines represent a significant advancement in cellular models used for molecular biology and genetic research. These cell lines are specifically engineered to lack the DCAF13 gene, which encodes a protein known for its role in ubiquitination and the regulation of cellular responses to stress. By providing a controlled and reproducible genetic environment, these knockout cell lines allow researchers to investigate the diverse biological functions of DCAF13 and its impact on processes such as DNA repair, proliferation, and apoptosis.

The primary mechanism through which DCAF13 influences cellular behavior involves its interaction with various ubiquitin ligases, thereby regulating the degradation of target proteins. This knockout enables researchers to dissect the downstream effects of DCAF13 loss and explore its contributions to key pathways relevant to cancer biology, neurodegenerative disorders, and metabolic syndromes. The valuable insights gained from these studies enhance our understanding of pathophysiological conditions and can contribute to the development of new therapeutic approaches.

In terms of scientific importance, DCAF13 Gene Knockout Cell Lines serve as essential tools in both basic and applied research settings. They facilitate the exploration of gene function, study of disease models, and validation of potential drug targets, significantly accelerating the pace of discovery in biomedical science.

When compared to conventional methods of gene manipulation, these knockout cell lines offer unique advantages, including consistent genetic background, reduced experimental variability, and ease of use across multiple experimental conditions. They simplify the workflow of gene function studies, providing reliability that is crucial for high-stakes research endeavors.

For researchers and clinicians alike, the availability of DCAF13 Gene Knockout Cell Lines is invaluable—they promise to drive innovative research forward, allowing for breakthroughs that can lead to novel biomarker identification and personalized medicine strategies.

Our company brings years of expertise in producing high-quality genetic models and remains committed to supporting the scientific community with cutting-edge tools that enhance research capabilities and therapeutic discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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