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DAPK1 Knockout Cell Lines

Gene: DAPK1

Official Full Name: death associated protein kinase 1provided by HGNC

Gene Summary: Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02247 DAPK1 Knockout cell line (HeLa) Human DAPK1 1:3~1:6 Negative Online Inquiry
KO02248 DAPK1 Knockout cell line (HCT 116) Human DAPK1 1:2~1:4 Negative Online Inquiry
KO02249 DAPK1 Knockout cell line (HEK293) Human DAPK1 1:3~1:6 Negative Online Inquiry
KO02250 DAPK1 Knockout cell line (A549) Human DAPK1 1:3~1:4 Negative Online Inquiry

Background

DAPK1 Gene Knockout Cell Lines are genetically engineered cellular models characterized by the silencing of the DAPK1 (Death-Associated Protein Kinase 1) gene, which plays a crucial role in various cellular processes including apoptosis, autophagy, and inflammation. By employing CRISPR-Cas9 and other gene-editing technologies, these cell lines provide researchers with the ability to study the specific functions and mechanisms of DAPK1 in a controlled environment.

The primary function of DAPK1 is to mediate cell death responses in the context of stress and disease, making it a significant target for investigations into cancer biology, neurodegenerative disorders, and immune response. The knockout of DAPK1 allows for the delineation of its role in apoptotic pathways, enabling scientists to examine alterations in cellular behavior such as proliferation, migration, and survival. Furthermore, these models are invaluable in translational research, as they facilitate the development of therapeutics aimed at modulating DAPK1 activity.

The scientific importance of DAPK1 knockout cell lines is underscored by their diverse applications in both fundamental research and clinical settings. They serve as powerful tools in drug discovery, allowing researchers to screen for compounds that can selectively target cells with altered DAPK1 pathways. Compared to traditional cell lines, DAPK1 knockout lines provide a more accurate representation of physiological conditions, offering enhanced reliability in experimental results.

What sets our DAPK1 Gene Knockout Cell Lines apart from competitors is the precision of our gene-editing technique and the rigorous validation processes our cell lines undergo. Each cell line is extensively characterized for genetic integrity and functional consistency, ensuring researchers can obtain accurate and reproducible data.

These knockout cell lines are indispensable for researchers and clinicians focused on understanding the multifaceted role of DAPK1 in health and disease. By leveraging our expertise in gene editing and cell line development, we are committed to providing high-quality biological products that propel scientific advancements and improve clinical outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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