Gene: DACH2
Official Full Name: dachshund family transcription factor 2provided by HGNC
Gene Summary: This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30452 | DACH2 Knockout cell line (HEK293) | Human | DACH2 | 1:3~1:6 | Negative | Online Inquiry |
DACH2 Gene Knockout Cell Lines are advanced cellular models designed specifically for the study of the DACH2 gene, which encodes a vital transcriptional regulator implicated in various biological processes such as cell differentiation, proliferation, and developmental signaling pathways. These knockout cell lines have been meticulously engineered through CRISPR/Cas9 technology to silence DACH2 gene expression, enabling researchers to dissect the functional role of DACH2 in cellular physiology and its potential contributions to disease states.
The key function of DACH2 Gene Knockout Cell Lines lies in their ability to facilitate the investigation of gene function by employing a loss-of-function approach. By eliminating the DACH2 gene, these cell lines allow scientists to observe downstream effects on gene expression, cellular behavior, and signaling pathways, thereby providing insights into the biological ramifications of DACH2 dysregulation. This characteristic is particularly crucial for studying developmental disorders, cancer biology, and regenerative medicine.
Scientifically, these cell lines serve as a cornerstone in both research and clinical applications. They facilitate high-throughput screening for novel therapeutic compounds and aid in elucidating the molecular mechanisms underlying various pathologies. In drug discovery, the DACH2 knockout models could prove invaluable in validating targets for pharmacological intervention.
One of the standout advantages of our DACH2 Gene Knockout Cell Lines is their high specificity and efficiency, achieved through precise editing techniques that minimize off-target effects. Compared to traditional knockdown methods such as RNA interference, our knockout models offer a more stable and permanent solution, enhancing the reliability of experimental outcomes.
For researchers and clinicians, the availability of DACH2 Gene Knockout Cell Lines represents a powerful tool for advancing the understanding of gene function and disease mechanisms. With the trend toward personalized medicine and targeted therapies, these models contribute substantially to bridging the gap between basic research and clinical applications.
Backed by our commitment to excellence in genetic engineering and cell line development, our company stands at the forefront of producing high-quality biological research tools, ensuring that our customers access reliable and innovative solutions tailored to meet the challenges of modern scientific inquiry.
Please note that all services are for research use only. Not intended for any clinical use.
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