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CYP4V2 Knockout Cell Lines

Gene: CYP4V2

Official Full Name: cytochrome P450 family 4 subfamily V member 2provided by HGNC

Gene Summary: This gene encodes a member of the cytochrome P450 hemethiolate protein superfamily which are involved in oxidizing various substrates in the metabolic pathway. It is implicated in the metabolism of fatty acid precursors into n-3 polyunsaturated fatty acids. Mutations in this gene result in Bietti crystalline corneoretinal dystrophy. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18444 CYP4V2 Knockout cell line (HCT 116) Human CYP4V2 1:2~1:4 Negative Online Inquiry
KO18445 CYP4V2 Knockout cell line (HEK293) Human CYP4V2 1:3~1:6 Negative Online Inquiry
KO18446 CYP4V2 Knockout cell line (A549) Human CYP4V2 1:3~1:4 Negative Online Inquiry

Background

CYP4V2 Gene Knockout Cell Lines are specialized cellular models designed to study the functional consequences of the CYP4V2 gene, which encodes a member of the cytochrome P450 family of enzymes involved in the metabolism of fatty acids and the biosynthesis of lipids. These knockout cell lines have been meticulously engineered to exhibit a complete inactivation of the CYP4V2 gene, allowing researchers to investigate the biological pathways and physiological roles that this enzyme plays in human health, particularly in relation to metabolic disorders and cardiovascular diseases.

The key function of these cell lines lies in their ability to enable in vitro studies of the metabolic processes that are perturbed when CYP4V2 is absent. By applying CRISPR/Cas9 technology for precise gene editing, researchers can analyze metabolic pathways, assess the impact of CYP4V2 loss on lipid metabolism, and explore potential therapeutic targets. This system provides crucial insights into how the loss of CYP4V2 can contribute to disease development, offering a platform for validating drug efficacy and safety.

In both research and clinical contexts, the CYP4V2 Gene Knockout Cell Lines are invaluable for pharmacogenomic studies, as they facilitate the understanding of individual variability in drug metabolism based on CYP P450 activities. Furthermore, these cell lines can serve as a robust model for elucidating the roles of enzymes in lipid-related conditions, which are increasingly recognized as significant contributors to various diseases.

What sets our CYP4V2 Gene Knockout Cell Lines apart from alternative models is their high degree of specificity and reliability, which reduces confounding variables inherent in standard cellular models. Our commitment to rigorous quality control ensures that these lines maintain the integrity and reproducibility necessary for cutting-edge research.

By choosing our product, researchers and clinicians gain access to a premier tool that enhances their ability to dissect complex metabolic pathways, investigate disease mechanisms, and develop targeted therapeutic interventions. Our company, with its deep expertise in genetic engineering and cellular biology, is dedicated to providing innovative solutions that empower scientific discovery and advance the field of biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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