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CYP20A1 Knockout Cell Lines

Gene: CYP20A1

Official Full Name: cytochrome P450 family 20 subfamily A member 1provided by HGNC

Gene Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18439 CYP20A1 Knockout cell line (HeLa) Human CYP20A1 1:3~1:6 Negative Online Inquiry
KO18440 CYP20A1 Knockout cell line (HCT 116) Human CYP20A1 1:2~1:4 Negative Online Inquiry
KO18441 CYP20A1 Knockout cell line (HEK293) Human CYP20A1 1:3~1:6 Negative Online Inquiry
KO18442 CYP20A1 Knockout cell line (A549) Human CYP20A1 1:3~1:4 Negative Online Inquiry

Background

CYP20A1 Gene Knockout Cell Lines are specially engineered cellular systems in which the CYP20A1 gene has been deliberately disrupted, enabling the study of its biological functions and implications in various physiological and pathological contexts. These knockout models provide a unique tool for investigating the roles of cytochrome P450 enzymes in metabolic processes, drug metabolism, and disease progression.

The primary function of these cell lines is to elucidate the impact of the CYP20A1 gene on cellular metabolism and signaling pathways. By inactivating this specific gene, researchers can better understand how the absence of its enzymatic activity affects various cellular processes, including hormone synthesis, inflammation responses, and xenobiotic detoxification. This is particularly critical in uncovering the underlying mechanisms of diseases such as cancer and metabolic disorders, where CYP20A1 may play a significant role.

The scientific importance of CYP20A1 Gene Knockout Cell Lines extends to their applications in both research and clinical settings. They serve as invaluable models for drug discovery, toxicology studies, and biomarker development, enhancing the understanding of how genetic variations influence drug response and metabolism. Moreover, the insights gained from these models can facilitate the design of targeted therapies and personalized medicine strategies.

Compared to alternative models, such as wild-type cell lines or transient transfection systems, the knockout cell lines offer unparalleled specificity and stability, allowing for reproducible results over extended experimental periods. This specificity reduces the complexity associated with compensatory mechanisms that often confound results in less precise models.

For researchers and clinicians, the CYP20A1 Gene Knockout Cell Lines represent a significant opportunity to advance knowledge in pharmacogenomics and toxicology. By providing a clean slate to study the precise roles of CYP20A1, these cell lines can accelerate the development of effective therapies and improve clinical outcomes.

With a deep commitment to innovation and excellence in cellular models, our company stands at the forefront of creating high-quality biological products. We leverage cutting-edge technology and a team of experts to ensure that our offerings meet the rigorous needs of researchers and clinicians alike.

Please note that all services are for research use only. Not intended for any clinical use.

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