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CXCL1 Knockout Cell Lines

Gene: CXCL1

Official Full Name: C-X-C motif chemokine ligand 1provided by HGNC

Gene Summary: This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11097 CXCL1 Knockout cell line (HeLa) Human CXCL1 1:3~1:6 Negative Online Inquiry
KO11098 CXCL1 Knockout cell line (HCT 116) Human CXCL1 1:2~1:4 Negative Online Inquiry
KO11099 CXCL1 Knockout cell line (A549) Human CXCL1 1:3~1:4 Negative Online Inquiry

Background

CXCL1 Gene Knockout Cell Lines are genetically modified cell lines specifically designed to facilitate the study of the CXCL1 gene, which encodes for a chemokine involved in various physiological and pathological processes, including inflammation, immune responses, and tumor progression. By utilizing CRISPR/Cas9 technology, these cell lines have been engineered to lack functional CXCL1 genes, providing researchers with a powerful tool to elucidate the gene's role in cellular signaling and its contributions to disease mechanisms.

Key functions of CXCL1 include its ability to attract neutrophils to sites of inflammation, thus playing a critical role in innate immunity. By studying these gene knockout cell lines, researchers can investigate the downstream effects of CXCL1 absence on cell behavior, including alterations in migration, proliferation, and cytokine production. This model is particularly valuable for examining disease states such as cancer, where CXCL1 is implicated in tumor growth and metastasis, providing insights that are essential for the development of therapeutic strategies.

The scientific importance of CXCL1 Gene Knockout Cell Lines extends to diverse applications in both research and clinical settings. These cell lines can be utilized in high-throughput screening assays to identify novel anti-inflammatory compounds or in the development of biomarker studies for cancer progression. Moreover, they offer an opportunity for researchers to create preclinical models that may predict responses to therapies targeting chemokine signaling pathways.

What sets our CXCL1 Gene Knockout Cell Lines apart from alternatives is the precision of the gene-editing process, ensuring a complete and specific knockout that enhances the reliability of experimental outcomes. Additionally, these cell lines are rigorously validated and come with detailed characterization data, providing researchers with confidence in their utility.

For researchers and clinicians focused on understanding immune mechanisms or developing novel treatments, our CXCL1 Gene Knockout Cell Lines offer a unique and impactful resource. They simplify complex experimental designs while facilitating high-quality, reproducible results. With a commitment to advancing biological research, our company leverages extensive expertise in gene editing and cellular model development, ensuring that our products meet the highest standards of scientific excellence.

Please note that all services are for research use only. Not intended for any clinical use.

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