Gene: CTSK
Official Full Name: cathepsin Kprovided by HGNC
Gene Summary: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02497 | CTSK Knockout cell line (HeLa) | Human | CTSK | 1:3~1:6 | Negative | Online Inquiry |
KO02498 | CTSK Knockout cell line (HCT 116) | Human | CTSK | 1:2~1:4 | Negative | Online Inquiry |
KO02499 | CTSK Knockout cell line (A549) | Human | CTSK | 1:3~1:4 | Negative | Online Inquiry |
CTSK Gene Knockout Cell Lines are genetically engineered cell lines that have been specifically designed to knock out the cathepsin K (CTSK) gene, a critical component implicated in various physiological and pathological processes. Cathepsin K, a cysteine protease, is primarily known for its role in bone resorption and has been associated with conditions such as osteoporosis and arthritis. The knockdown of this gene allows researchers to explore its functions and the downstream effects of its absence, thereby enabling a deeper understanding of bone metabolism and related disorders.
These cell lines utilize advanced CRISPR-Cas9 technology for precise and efficient gene editing. By knocking out the CTSK gene, researchers can investigate the molecular pathways influenced by cathepsin K and identify potential therapeutic targets or biomarkers. The ability to observe the cellular response without the confounding effects of CTSK opens new avenues for drug discovery and the development of novel treatments for bone-related diseases.
The scientific importance of CTSK Gene Knockout Cell Lines extends to both basic research and clinical applications. They provide invaluable insights into osteoclast function, bone remodeling, and metabolic dysfunctions, making them crucial tools for pharmaceutical research and bioengineering. Their application can also extend to regenerative medicine, as understanding the mechanisms of bone degradation could lead to improved strategies for tissue engineering.
One of the standout advantages of CTSK Gene Knockout Cell Lines is their robustness and specificity. Unlike traditional methods of gene silencing, such as siRNA, which may lead to off-target effects, these knockout models provide a more definitive approach to understanding gene function. Furthermore, these cell lines can be easily adapted to high-throughput screening formats, making them ideal for researchers aiming to expedite their studies.
For researchers and clinicians, the value of CTSK Gene Knockout Cell Lines lies in their potential to drive innovation and discovery in the fields of bone health and disease. The findings from studies utilizing these cell lines could not only contribute to enhanced knowledge but also promote the development of targeted therapies that address underlying bone pathologies.
Our company specializes in providing high-quality biological products founded on rigorous scientific principles and advanced biotechnology. We are committed to supporting the research community with reliable tools, such as the CTSK Gene Knockout Cell Lines, that empower scientists to push the boundaries of knowledge and develop groundbreaking solutions in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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