Gene: CTSH
Official Full Name: cathepsin Hprovided by HGNC
Gene Summary: The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO06653 | CTSH Knockout cell line (HeLa) | Human | CTSH | 1:3~1:6 | Negative | Online Inquiry |
KO06654 | CTSH Knockout cell line (HCT 116) | Human | CTSH | 1:2~1:4 | Negative | Online Inquiry |
KO06655 | CTSH Knockout cell line (A549) | Human | CTSH | 1:3~1:4 | Negative | Online Inquiry |
CTSH Gene Knockout Cell Lines are advanced biological models designed to facilitate the study of the cathepsin H gene (CTSH) and its associated functions in cellular processes. These cell lines have been genetically engineered to disable the CTSH gene, allowing researchers to investigate the role of cathepsin H in various biological contexts, such as apoptosis, cellular signaling, and extracellular matrix remodeling.
The key functionality of CTSH Gene Knockout Cell Lines lies in their capacity to elucidate the biological consequences of CTSH deficiency. By observing how the absence of this gene influences cellular behavior, researchers can gain insights into its contributions to normal physiology and disease states, including cancer and neurodegenerative disorders. The meticulous gene editing achieved through CRISPR/Cas9 technology ensures precision in the knockout process, thereby maintaining the overall integrity of the cell lines for accurate studies.
The scientific importance of CTSH Gene Knockout Cell Lines is profound, as it allows for targeted research that may lead to the identification of novel therapeutic targets. These cell lines are especially valuable in translational research, serving as instrumental models in drug discovery and development processes, where the impact of potential therapeutic agents on CTSH-deficient cells can be tested under controlled conditions.
Compared to other gene knockout models, CTSH-specific lines offer the unique advantage of addressing a specific pathway associated with protein catabolism and immune response, which are crucial in various disease mechanisms. Moreover, the reliability and reproducibility of results from these cell lines enhance the data quality, making them superior choices for researchers looking to maximize the impact of their findings.
Incorporating CTSH Gene Knockout Cell Lines into your research toolkit not only accelerates your understanding of cathepsin H functionalities but also contributes to the advancement of therapeutic strategies targeting CTSH-related pathologies. Our company prides itself on high-quality biological products, backed by a team of experts in gene editing and cellular biology, dedicated to delivering reliable models that empower researchers and clinicians alike.
Please note that all services are for research use only. Not intended for any clinical use.
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