Gene: CRY1
Official Full Name: cryptochrome circadian regulator 1provided by HGNC
Gene Summary: This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04113 | CRY1 Knockout cell line (HeLa) | Human | CRY1 | 1:3~1:6 | Negative | Online Inquiry |
KO04114 | CRY1 Knockout cell line (HCT 116) | Human | CRY1 | 1:2~1:4 | Negative | Online Inquiry |
KO04115 | CRY1 Knockout cell line (HEK293) | Human | CRY1 | 1:3~1:6 | Negative | Online Inquiry |
KO04116 | CRY1 Knockout cell line (A549) | Human | CRY1 | 1:3~1:4 | Negative | Online Inquiry |
CRY1 Gene Knockout Cell Lines are genetically modified cell models specifically engineered to lack the expression of the CRY1 gene, which encodes the cryptochrome 1 protein. This protein plays a crucial role in the regulation of circadian rhythms, influencing various physiological and metabolic processes. The CRY1 gene knockout results in altered cellular responses to light and environmental cues, making these cell lines invaluable for studying the molecular mechanisms underlying circadian biology.
The primary function of CRY1 Gene Knockout Cell Lines is to facilitate research into the pathways and interactions mediated by the circadian clock. By observing the behavior and physiological responses of these knockout cells, researchers can elucidate the impacts of disrupted circadian rhythms on various biological functions, from metabolism and hormone secretion to cell proliferation and apoptosis. Moreover, these cell lines serve as powerful tools for drug discovery, allowing for the evaluation of pharmacological interventions that address circadian-related disorders such as sleep disturbances and metabolic syndromes.
The scientific importance of these cell lines extends into diverse research fields, including cancer biology, neurobiology, and pharmacology. Their ability to mimic the effects of circadian dysregulation presents unique opportunities to explore novel therapeutic targets and understand the broader implications of circadian disruptions in human health.
Compared to alternative models, CRY1 Gene Knockout Cell Lines provide a robust platform with specific attention to circadian functionality, ensuring that researchers can obtain reliable data relevant to their hypotheses. These cell lines offer unparalleled versatility for experimentation in both basic and applied research, thus enhancing their utility in both academic laboratories and clinical settings.
For researchers and clinicians seeking to advance their work in circadian biology and related disciplines, CRY1 Gene Knockout Cell Lines offer significant advantages. The tailored modifications enhance experimental precision, leading to more reproducible and relevant insights.
Our company specializes in the provision of high-quality biological products, including advanced cell lines that support scientific innovation. With expertise in genetic engineering and cell biology, we are dedicated to equipping the research community with tools that drive discovery and foster advancements in healthcare.
Please note that all services are for research use only. Not intended for any clinical use.
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