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CRLF3 Knockout Cell Lines

Gene: CRLF3

Official Full Name: cytokine receptor like factor 3provided by HGNC

Gene Summary: This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22594 CRLF3 Knockout cell line (HeLa) Human CRLF3 1:3~1:6 Negative Online Inquiry
KO22595 CRLF3 Knockout cell line (HCT 116) Human CRLF3 1:2~1:4 Negative Online Inquiry
KO22596 CRLF3 Knockout cell line (HEK293) Human CRLF3 1:3~1:6 Negative Online Inquiry
KO22597 CRLF3 Knockout cell line (A549) Human CRLF3 1:3~1:4 Negative Online Inquiry

Background

CRLF3 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to disrupt the function of the CRLF3 gene. CRLF3 (cytokine receptor-like factor 3) plays a crucial role in various cellular processes, including immune signaling and hematopoiesis. By utilizing CRLF3 gene knockout technology, these cell lines allow researchers to study the effects of CRLF3 loss on cellular behavior, gene expression, and signaling pathways, providing significant insights into its role in health and disease.

The key mechanism underlying the functionality of CRLF3 Gene Knockout Cell Lines is the targeted gene disruption achieved through advanced genome-editing techniques such as CRISPR-Cas9. This precise editing allows for the creation of knockout cells that completely lack functional CRLF3 protein, facilitating investigations into resulting phenotypic changes. The ablation of CRLF3 can lead to alterations in cytokine signaling and transcription factor activity, making these cell lines invaluable tools for elucidating the gene's role in pathologies including certain cancers and autoimmune diseases.

In research and clinical settings, CRLF3 Gene Knockout Cell Lines hold immense scientific significance. They serve as a model for studying tumor biology, immune disorders, and the development of novel therapeutic approaches. By providing insights into cellular responses against various treatments or conditions, these cell lines can help identify new biomarkers and therapeutic targets.

Compared to traditional methods of gene editing, such as RNA interference, CRLF3 Gene Knockout Cell Lines provide a permanent and highly specific knockout of the gene, ensuring consistent results across experiments. They offer greater reliability and reproducibility for experimental outcomes, setting a new standard in genetic research.

The value of these cell lines to researchers and clinicians lies in their ability to facilitate groundbreaking discoveries and enhance understanding of complex biological mechanisms. The insights gained have the potential to translate into innovative diagnostic and therapeutic strategies, paving the way for improved patient outcomes.

With extensive expertise in genomic technologies and a commitment to advancing scientific research, our company is dedicated to providing high-quality biological products such as the CRLF3 Gene Knockout Cell Lines. We strive to empower the scientific community with reliable tools that foster innovation and drive progress in the field of molecular and cellular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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