Gene: CRK
Official Full Name: CRK proto-oncogene, adaptor proteinprovided by HGNC
Gene Summary: This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10888 | CRK Knockout cell line (HeLa) | Human | CRK | 1:3~1:6 | Negative | Online Inquiry |
KO10889 | CRK Knockout cell line (HCT 116) | Human | CRK | 1:2~1:4 | Negative | Online Inquiry |
KO10890 | CRK Knockout cell line (HEK293) | Human | CRK | 1:3~1:6 | Negative | Online Inquiry |
CRK Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to lack the expression of the CRK gene, a key player in various cellular processes, including signal transduction, cell adhesion, and migration. This innovative tool enables researchers to dissect the functional roles of the CRK gene and its associated pathways with precision. By utilizing CRISPR/Cas9 technology, our cell lines provide an effective platform for studying gene function, elucidating mechanisms of disease, and exploring therapeutic targets.
The primary function of CRK Gene Knockout Cell Lines is to enable the investigation of CRK-related signaling pathways. The absence of the CRK protein provides insights into how cells respond to environmental stimuli and communicate with surrounding cells. Researchers can observe changes in cell behavior, proliferation, and chemotaxis, leading to crucial discoveries in cancer biology, developmental biology, and immunology. These knockout cell lines can serve as functional assays for testing novel compounds that could modulate the CRK pathway, with implications for drug development and therapeutic strategies.
In the scientific landscape, these cell lines hold significant importance for both research and clinical applications. They allow for controlled experiments that can reveal the phenotypic consequences of CRK loss, facilitating breakthroughs in understanding tumor progression and metastasis. Additionally, CRK knockouts are invaluable tools in the development of gene therapies and understanding pathogenic mechanisms in various diseases.
What sets our CRK Gene Knockout Cell Lines apart from alternatives on the market is our commitment to quality and reliability. Each cell line is rigorously validated for complete gene knockout, ensuring that researchers obtain reproducible and relevant results. Furthermore, our user-friendly protocols and comprehensive support for experimental design enhance the research experience, making it accessible even for researchers who may not have extensive experience with knockout models.
The CRK Gene Knockout Cell Lines are indispensable for any laboratory seeking to advance their understanding of gene function and develop innovative therapeutic strategies. Our company prides itself on its expertise in creating high-quality biological products that meet the evolving needs of the research community, with a focus on reliability, support, and scientific integrity.
Please note that all services are for research use only. Not intended for any clinical use.
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