Home / CRAT Knockout Cell Lines

CRAT Knockout Cell Lines

Gene: CRAT

Official Full Name: carnitine O-acetyltransferaseprovided by HGNC

Gene Summary: This gene encodes carnitine O-acetyltransferase, a member of the carnitine acyltransferase family and a key metabolic pathway enzyme which plays an important role in energy homeostasis and fat metabolism. This enzyme catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acyl-CoA/CoA. It is found in both the mitochondria and the peroxisome. Alternative splicing results in transcript variants encoding different isoforms that may localize to different subcellular compartments. [provided by RefSeq, Oct 2016]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05483 CRAT Knockout cell line (HeLa) Human CRAT 1:3~1:6 Negative Online Inquiry
KO05484 CRAT Knockout cell line (HCT 116) Human CRAT 1:2~1:4 Negative Online Inquiry
KO05485 CRAT Knockout cell line (A549) Human CRAT 1:3~1:4 Negative Online Inquiry

Background

CRAT Gene Knockout Cell Lines represent a significant advancement in genetic manipulation, specifically designed to study the role of the Crat gene in cellular processes. These cell lines are created using cutting-edge CRISPR-Cas9 technology, leading to precise deletions in the CRAT gene, which encodes for the enzyme Carnitine O-palmitoyltransferase 1. This enzyme plays a crucial role in the metabolism of fatty acids, making the CRAT gene indispensable for understanding various metabolic pathways and their implications in health and disease.

The primary function of CRAT Gene Knockout Cell Lines is to facilitate in-depth research into lipid metabolism, mitochondrial function, and cellular energy homeostasis. By observing the phenotypic and metabolic changes in these knockout models, researchers can elucidate the physiological functions of the CRAT gene and its influence on diseases such as obesity, diabetes, and cardiovascular disorders. The use of these cell lines sets the foundation for identifying potential therapeutic targets and developing innovative treatment strategies.

Scientific importance lies in their applicability for both basic and translational research. In clinical settings, this tool can lead to discoveries of biomarkers for metabolic conditions, thus enhancing the capacity for early diagnosis and personalized medicine approaches.

Compared to traditional gene-editing methods, the CRAT Gene Knockout Cell Lines offer faster generation times, higher efficiency in terms of knockout rates, and a more streamlined approach to genetic assessment, making them superior for high-throughput experimental platforms.

For researchers and clinicians striving to push the boundaries of understanding metabolic diseases, these cell lines deliver unparalleled opportunities to make significant contributions to the field. Our company, renowned for its commitment to innovation in biological products, provides CRAT Gene Knockout Cell Lines with high reproducibility and quality assurance, ensuring that your research efforts yield reliable and meaningful data.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.