Gene: CRADD
Official Full Name: CASP2 and RIPK1 domain containing adaptor with death domainprovided by HGNC
Gene Summary: This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33904 | CRADD Knockout cell line (HeLa) | Human | CRADD | 1:3~1:6 | Negative | Online Inquiry |
KO33905 | CRADD Knockout cell line (HCT 116) | Human | CRADD | 1:2~1:4 | Negative | Online Inquiry |
KO33906 | CRADD Knockout cell line (HEK293) | Human | CRADD | 1:3~1:6 | Negative | Online Inquiry |
KO33907 | CRADD Knockout cell line (A549) | Human | CRADD | 1:3~1:4 | Negative | Online Inquiry |
CRADD Gene Knockout Cell Lines are specially engineered cell lines designed to facilitate the study of the CRADD (Caspase Recruitment Domain-Containing Protein) gene. These knockout cell lines are generated using CRISPR-Cas9 technology, ensuring precise editing of the CRADD gene, which plays a critical role in cellular processes such as apoptosis, inflammation, and signal transduction. By removing the functional CRADD gene, researchers can observe and analyze the biological ramifications of its absence, providing valuable insights into its role in health and disease.
The key functions of CRADD Gene Knockout Cell Lines include enabling the investigation of cellular pathways influenced by CRADD. The absence of CRADD allows for a clearer understanding of its interactions with other proteins involved in apoptotic pathways and its potential mechanisms of action in various diseases, including cancer and neurodegenerative disorders. Researchers can utilize these cell lines to conduct functional assays, drug sensitivity tests, and molecular profiling, thereby accelerating the discovery of therapeutic targets.
From a scientific standpoint, the CRADD Gene Knockout Cell Lines offer substantial applications in both basic and translational research settings. Their capacity to elucidate the role of CRADD in pathological conditions aids in developing targeted therapies and personalized medicine approaches. Moreover, they provide a reliable model for studying gene function, making them invaluable tools for academic institutions, pharmaceutical companies, and biotechnology firms alike.
Compared to alternative models, CRADD Gene Knockout Cell Lines stand out due to their meticulous design and reproducibility. Traditional knockout models often present variability, but the precision of CRISPR-Cas9 technology yields cell lines that exhibit consistent phenotype expression changes, thus enhancing experimental reliability. Our cell lines are validated with comprehensive characterizations, providing users with confidence in their research outcomes.
For researchers and clinicians aiming to unravel complex biological questions or develop new therapeutic strategies, CRADD Gene Knockout Cell Lines represent a powerful resource. Our commitment to quality and innovation ensures that these tools not only meet but exceed the expectations of the scientific community. With years of expertise in genetic engineering and cellular biology, our company is dedicated to advancing research and fostering discoveries that drive meaningful advancements in health.
Please note that all services are for research use only. Not intended for any clinical use.
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