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CPLX2 Knockout Cell Lines

Gene: CPLX2

Official Full Name: complexin 2provided by HGNC

Gene Summary: Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31487 CPLX2 Knockout cell line (A549) Human CPLX2 1:3~1:4 Negative Online Inquiry

Background

CPLX2 Gene Knockout Cell Lines are specialized cellular models developed for the study of synaptic transmission and neurological diseases, specifically aimed at providing insights into the functions of the complexin 2 (CPLX2) gene. These cell lines are meticulously engineered using CRISPR/Cas9 technology, resulting in a precise knockout of the CPLX2 gene, which plays a critical role in synaptic vesicle exocytosis and neurotransmitter release.

The key function of these cell lines lies in their ability to mimic physiological conditions that are essential for investigating the molecular underpinnings of synaptic function and plasticity. By eliminating the CPLX2 gene, researchers can examine changes in synaptic dynamics, assess the impact on neuronal communication, and explore the gene's involvement in neurodevelopmental and neurodegenerative disorders. This model serves as a foundational tool for unraveling the complexities of synaptic signaling.

Scientifically, the CPLX2 Gene Knockout Cell Lines are invaluable in both basic and applied research settings. In academic and pharmaceutical environments, they facilitate the discovery of potential therapeutic targets and drug efficacy studies. Their application extends to screening compounds that may rectify or aggravate the phenotypic consequences of CPLX2 deficiency, providing a significant advantage in translational research.

Compared to alternative models, these cell lines offer enhanced specificity and control over gene expression, allowing researchers to delve deeper into the mechanistic insights that other models may not provide. The robustness of the CRISPR/Cas9 technology ensures high-efficiency editing and consistent performance across experiments.

For researchers and clinicians focused on neurobiology, the CPLX2 Gene Knockout Cell Lines represent a transformative resource, delivering unparalleled capabilities for advancing understanding in neurological studies. By utilizing these sophisticated tools, users can engage in groundbreaking research with potential implications for developing therapeutic interventions.

At our company, we pride ourselves on our commitment to cutting-edge genetic engineering solutions and the production of high-quality biological products, ensuring that our clients have access to the latest innovations in research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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