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CPEB4 Knockout Cell Lines

Gene: CPEB4

Official Full Name: cytoplasmic polyadenylation element binding protein 4provided by HGNC

Gene Summary: Enables RNA binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; negative regulation of cytoplasmic translation; and response to ischemia. Located in cytoplasm and nucleus. Biomarker of liver cirrhosis; portal hypertension; and primary biliary cholangitis. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26043 CPEB4 Knockout cell line (HeLa) Human CPEB4 1:3~1:6 Negative Online Inquiry
KO26044 CPEB4 Knockout cell line (HCT 116) Human CPEB4 1:2~1:4 Negative Online Inquiry
KO26045 CPEB4 Knockout cell line (HEK293) Human CPEB4 1:3~1:6 Negative Online Inquiry
KO26046 CPEB4 Knockout cell line (A549) Human CPEB4 1:3~1:4 Negative Online Inquiry

Background

CPEB4 Gene Knockout Cell Lines are specifically engineered cellular models that have had the cytoplasmic polyadenylation element-binding protein 4 (CPEB4) gene rendered inactive. These knockout cell lines serve a critical function in the study of gene regulation, mRNA metabolism, and cellular differentiation. CPEB4 plays a pivotal role in the control of polyadenylation and subsequent stability and translation of mRNAs, influencing various physiological processes. By silencing this gene, researchers can study its functional implications and unravel the molecular pathways influenced by CPEB4, thereby gaining insight into its contributions to cellular processes.

The mechanism of action for CPEB4 involves the regulation of mRNA translation through the binding of specific mRNA sequences, leading to polyadenylation, which ultimately affects gene expression. In the knockout model, researchers can observe changes in gene expression profiles and identify the biological consequences of CPEB4 loss-of-function, thus providing valuable insights into conditions related to gene dysregulation, such as cancers and neurological disorders.

From a scientific perspective, these cell lines are invaluable in both research and clinical applications. They enable the dissection of complex regulatory networks and the investigation of potential therapeutic targets. Their specificity allows for high-throughput screening and contributes to the understanding of gene-environment interactions. This makes them essential tools for researchers focusing on developmental biology, cancer research, and neurology.

Compared to alternative methods, such as RNA interference, the utilization of knockout cell lines offers permanent disruption of gene function, providing a more stable and controllable model for long-term studies. Additionally, the high specificity of these models helps to reduce off-target effects, enhancing the reliability of experimental outcomes.

CPEB4 Gene Knockout Cell Lines represent a powerful research tool for those aiming to elucidate the roles of CPEB4 in various biological processes. By enabling precise genetic manipulation and offering a more comprehensive understanding of mRNA regulation, these cell lines provide immense value to both researchers and clinicians who seek to advance knowledge and therapeutic approaches in gene regulation. Our company prides itself on delivering high-quality biological products and our expertise in gene editing methodologies ensures that these cell lines meet the rigorous standards demanded in modern research.

Please note that all services are for research use only. Not intended for any clinical use.

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