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CORO1C Knockout Cell Lines

Gene: CORO1C

Official Full Name: coronin 1Cprovided by HGNC

Gene Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04149 CORO1C Knockout cell line (HeLa) Human CORO1C 1:3~1:6 Negative Online Inquiry
KO04150 CORO1C Knockout cell line (HCT 116) Human CORO1C 1:2~1:4 Negative Online Inquiry
KO04151 CORO1C Knockout cell line (HEK293) Human CORO1C 1:3~1:6 Negative Online Inquiry
KO04152 CORO1C Knockout cell line (A549) Human CORO1C 1:3~1:4 Negative Online Inquiry

Background

CORO1C Gene Knockout Cell Lines are engineered cellular models designed for the specific deletion of the CORO1C gene, which encodes for a protein involved in critical cellular processes such as cytoskeletal dynamics, cell migration, and immune responses. This knockout technology utilizes CRISPR/Cas9 gene editing to precisely disrupt the CORO1C gene, facilitating the study of its biological functions and implications in various disease mechanisms.

The primary function of CORO1C Gene Knockout Cell Lines lies in their ability to elucidate the role of CORO1C in cellular interactions and signaling pathways. By observing phenotypic changes and molecular alterations in these cell models, researchers can perform in-depth analyses on the consequences of CORO1C deficiency, including impacts on cell motility, proliferation, and apoptosis. This can serve as a critical tool for understanding diseases that involve immune system dysregulation, cancer metastasis, and other pathologies linked to aberrant cytoskeletal functions.

Scientifically, these knockout cell lines are invaluable in both research and clinical settings. They allow investigators to explore novel therapeutic targets, validate biomarkers, and investigate the efficacy of therapeutic interventions. As CORO1C has been implicated in certain cancers and autoimmune disorders, these cell lines facilitate a deeper understanding of its role in disease and assist in the development of targeted therapies.

Compared to traditional cell lines, CORO1C Gene Knockout Cell Lines offer significant advantages by providing a specific genetic background devoid of confounding variables from the CORO1C protein. This heightened specificity enhances experimental reproducibility and reliability, making results more robust and applicable in translational research.

For researchers and clinicians, the CORO1C Gene Knockout Cell Lines represent a vital resource for advancing our understanding of cellular mechanisms and developing innovative therapeutic strategies. With expertise in gene editing technologies and cellular biology, our company is committed to delivering high-quality biological products that empower scientific discovery and drive advancements in healthcare.

Please note that all services are for research use only. Not intended for any clinical use.

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