Home / COQ3 Knockout Cell Lines

COQ3 Knockout Cell Lines

Gene: COQ3

Official Full Name: coenzyme Q3, methyltransferaseprovided by HGNC

Gene Summary: Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM, Mar 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22196 COQ3 Knockout cell line (HeLa) Human COQ3 1:3~1:6 Negative Online Inquiry
KO22197 COQ3 Knockout cell line (HCT 116) Human COQ3 1:2~1:4 Negative Online Inquiry
KO22198 COQ3 Knockout cell line (HEK293) Human COQ3 1:3~1:6 Negative Online Inquiry
KO22199 COQ3 Knockout cell line (A549) Human COQ3 1:3~1:4 Negative Online Inquiry

Background

COQ3 Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to disable the COQ3 gene, which is essential for the biosynthesis of coenzyme Q10 (CoQ10). CoQ10 plays a critical role in mitochondrial energy production, cell signaling, and antioxidant protection. By knocking out the COQ3 gene, researchers can elucidate the function of CoQ10 in various biological processes and disease states.

These knockout cell lines function primarily by hindering the synthesis of CoQ10, allowing investigators to explore the downstream effects of CoQ10 deficiency on metabolic pathways, oxidative stress responses, and cellular viability. Researchers can use these models to study diseases associated with mitochondrial dysfunction, such as Parkinson's disease and other neurodegenerative conditions, as well as conditions related to aging and cardiovascular health.

The scientific importance of COQ3 Gene Knockout Cell Lines is pronounced, as they provide a valuable tool for uncovering the mechanistic underpinnings of diseases and for screening potential therapeutic compounds. Additionally, these cell lines facilitate the study of alternative metabolic pathways that may compensate for the lack of CoQ10, offering insights into new treatment strategies.

Compared to other models, COQ3 Gene Knockout Cell Lines stand out due to their specificity and relevance to human health. Unlike standard cell lines that may retain COQ10 synthesis pathways, these knockout lines deliver more precise insights into the biological role of CoQ10 and its related pathways. This specificity is incredibly advantageous for researchers aiming to develop targeted therapies or interventions.

For researchers and clinicians focused on mitochondrial research or related clinical applications, COQ3 Gene Knockout Cell Lines represent an essential tool in the realm of cellular biology. Their capacity to enhance our understanding of fundamental biochemical processes makes them invaluable in both academic and pharmaceutical research settings.

Our company excels in developing cutting-edge biological reagents, offering a comprehensive range of genetically modified cell lines that support advanced research across multiple disciplines. With a commitment to quality and innovation, we empower scientists with the tools they need to make significant contributions to their fields.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.