Gene: COA6
Official Full Name: cytochrome c oxidase assembly factor 6provided by HGNC
Gene Summary: This gene encodes a member of the cytochrome c oxidase subunit 6B family. The encoded protein associates with cytochrome c oxidase may act has an cytochrome c oxidase mitochondrial respiratory complex VI assembly factor. Mutations in this gene may be associated with fatal infantile cardiomyopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18618 | COA6 Knockout cell line (HeLa) | Human | COA6 | 1:3~1:6 | Negative | Online Inquiry |
KO18619 | COA6 Knockout cell line (HCT 116) | Human | COA6 | 1:2~1:4 | Negative | Online Inquiry |
KO18620 | COA6 Knockout cell line (HEK293) | Human | COA6 | 1:3~1:6 | Negative | Online Inquiry |
KO18621 | COA6 Knockout cell line (A549) | Human | COA6 | 1:3~1:4 | Negative | Online Inquiry |
COA6 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to disrupt the COA6 gene, which plays a critical role in mitochondrial function and cellular metabolism. By employing advanced CRISPR-Cas9 gene-editing technology, these cell lines provide researchers with a powerful tool to investigate the biological roles of COA6, offering insights into mitochondrial biology and potential implications for diseases linked to mitochondrial dysfunction.
The primary mechanism through which COA6 Gene Knockout Cell Lines operate is through the interruption of the COA6 gene sequence, leading to the creation of non-functional COA6 proteins. This disruption facilitates the study of cellular pathways affected by COA6, including mitochondrial respiration and energy production. Such functional investigations are crucial for understanding the broader implications of mitochondrial health in various disorders, including neurodegeneration and metabolic syndromes.
Scientifically, these cell lines are integral to both basic research and translational applications in the fields of genetics and cell biology. They can be utilized in drug discovery processes, allowing researchers to probe the effects of potential therapeutics on cells with altered mitochondrial function. The COA6 knockout model is also pivotal for studying gene interactions and the cellular response to stressors, providing insights that could lead to novel treatment strategies for mitochondrial diseases.
What sets COA6 Gene Knockout Cell Lines apart from traditional cell lines and other knockout models is their precise genetic modification, resulting in a high degree of specificity and reliability. This facilitation of directed research reduces the variability often seen with more generalized models, thus enhancing the reproducibility and accuracy of experimental results.
For researchers and clinicians, the ability to examine the consequences of COA6 deficiency in a structured and predictable environment translates to tremendous value. By leveraging these knockout cell lines, users can accelerate their research timelines, drive insights into disease mechanisms, and ultimately, unlock new biological pathways essential for therapeutic intervention.
Our company specializes in cutting-edge genetic engineering and cellular biology solutions, backed by a team of experts dedicated to supporting the scientific community. With our COA6 Gene Knockout Cell Lines, we provide researchers with the tools needed to advance their understanding of mitochondrial biology while fostering the development of innovative therapies.
Please note that all services are for research use only. Not intended for any clinical use.
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