Gene: CNTNAP1
Official Full Name: contactin associated protein 1provided by HGNC
Gene Summary: The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. [provided by RefSeq, Jan 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34099 | CNTNAP1 Knockout cell line (HeLa) | Human | CNTNAP1 | 1:3~1:6 | Negative | Online Inquiry |
KO34100 | CNTNAP1 Knockout cell line (HCT 116) | Human | CNTNAP1 | 1:2~1:4 | Negative | Online Inquiry |
KO34101 | CNTNAP1 Knockout cell line (HEK293) | Human | CNTNAP1 | 1:3~1:6 | Negative | Online Inquiry |
KO34102 | CNTNAP1 Knockout cell line (A549) | Human | CNTNAP1 | 1:3~1:4 | Negative | Online Inquiry |
CNTNAP1 Gene Knockout Cell Lines are advanced biological products developed to facilitate research into the role of the CNTNAP1 gene, which encodes the contactin-associated protein 1. These cell lines have been specifically engineered to have targeted deletions of the CNTNAP1 gene, enabling scientists to study its contributions to cellular processes and disease mechanisms, particularly in neurological and myelination contexts.
The key function of these knockout cell lines lies in their ability to provide a controlled environment for investigating the biological implications of CNTNAP1 loss. By removing the gene, researchers can model various pathophysiological conditions, observe changes in cellular behavior, and assess the molecular cascades that contribute to disorders such as demyelinating diseases. The mechanistic insights gleaned from these studies can lead to a deeper understanding of the role of CNTNAP1 in neuronal stability, signaling, and interaction with other proteins.
Scientifically, CNTNAP1 Gene Knockout Cell Lines are invaluable in both research and clinical settings. They serve as potent tools for drug screening, biomarker discovery, and therapeutic development, particularly for conditions tied to myelination disorders. In preclinical research, they allow for a more nuanced evaluation of treatment efficacy, enhancing the translation of findings from bench to bedside.
One of the standout advantages of these knockout cell lines is their specificity and reproducibility compared to traditional methods, such as siRNA knockdown or CRISPR interference. This specificity enables researchers to dissect the role of CNTNAP1 without off-target effects, which can confound results and lead to ambiguous interpretations.
For researchers and clinicians alike, the value of the CNTNAP1 Gene Knockout Cell Lines is underscored by their ability to open new avenues in understanding complex diseases and developing targeted therapies. With a focus on innovation and scientific rigor, our company excels in providing premium biological products that empower researchers to unravel biological mysteries and contribute to groundbreaking discoveries in health and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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