Gene: CNST
Official Full Name: consortin, connexin sorting proteinprovided by HGNC
Gene Summary: Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex. Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks of gap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (del Castillo et al., 2010 [PubMed 19864490]).[supplied by OMIM, Jun 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18632 | CNST Knockout cell line (HeLa) | Human | CNST | 1:3~1:6 | Negative | Online Inquiry |
KO18633 | CNST Knockout cell line (HCT 116) | Human | CNST | 1:2~1:4 | Negative | Online Inquiry |
KO18634 | CNST Knockout cell line (HEK293) | Human | CNST | 1:3~1:6 | Negative | Online Inquiry |
KO18635 | CNST Knockout cell line (A549) | Human | CNST | 1:3~1:4 | Negative | Online Inquiry |
CNST Gene Knockout Cell Lines are innovative biological tools designed for precise gene editing, enabling researchers to investigate gene function and disease mechanisms with unparalleled specificity. These cell lines utilize CRISPR-Cas9 technology to create targeted knockouts of the CNST gene, which encodes a key enzyme involved in various cellular processes, including metabolism and cell signaling. By eliminating CNST expression, researchers can examine the resultant phenotypic alterations, providing critical insights into gene function and potential therapeutic targets.
The primary mechanism underlying CNST Gene Knockout Cell Lines involves the introduction of dual-guide RNA sequences that direct the Cas9 nuclease to specific genomic locations. This targeted approach leads to the introduction of double-strand breaks, subsequently resulting in gene disruption through error-prone DNA repair pathways. By having these cell lines readily available, scientists can bypass the often lengthy processes of developing knockout models from scratch, significantly accelerating research timelines.
The significance of CNST Gene Knockout Cell Lines extends to both fundamental research and clinical applications. In academic settings, they serve as valuable platforms for studying gene regulation, cellular responses to environmental changes, and metabolic dysregulation in disease contexts. Clinically, they hold promise for drug discovery and the identification of novel therapeutic routes for genetic disorders associated with CNST dysfunction.
What sets our CNST Gene Knockout Cell Lines apart from competing products is their robust validation and characterization, ensuring consistent and reproducible results across experiments. Coupled with comprehensive technical support from our team, these cell lines empower researchers to conduct high-quality experiments with confident outcomes.
The value of CNST Gene Knockout Cell Lines lies in their ability to facilitate groundbreaking research and therapeutics, making them indispensable resources for researchers and clinicians seeking to delve deeper into the molecular underpinnings of health and disease. Our company is dedicated to providing cutting-edge biological products backed by extensive expertise in gene editing technologies, ensuring our customers have reliable tools to drive their scientific endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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