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CNOT6 Knockout Cell Lines

Gene: CNOT6

Official Full Name: CCR4-NOT transcription complex subunit 6provided by HGNC

Gene Summary: This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20314 CNOT6 Knockout cell line (HeLa) Human CNOT6 1:3~1:6 Negative Online Inquiry
KO20315 CNOT6 Knockout cell line (HCT 116) Human CNOT6 1:2~1:4 Negative Online Inquiry
KO20316 CNOT6 Knockout cell line (HEK293) Human CNOT6 1:3~1:6 Negative Online Inquiry
KO20317 CNOT6 Knockout cell line (A549) Human CNOT6 1:3~1:4 Negative Online Inquiry

Background

CNOT6 gene knockout cell lines are engineered cellular models created by disrupting the function of the CNOT6 gene, which plays a crucial role in the regulation of mRNA decay and gene expression. These cell lines provide invaluable tools for studying the biological mechanisms underlying post-transcriptional regulation efficiently. By utilizing CRISPR/Cas9 gene editing technology or similar approaches, researchers can specifically knock out CNOT6, allowing for the detailed investigation of its impact on cellular processes such as proliferation, differentiation, and response to environmental cues.

The CNOT6 gene encodes a subunit of the Ccr4-Not complex, which is essential for the deadenylation of mRNA, thereby influencing gene expression and regulatory networks within the cell. Understanding these mechanisms is fundamental for exploring various biological phenomena, including cancer progression, neurodegenerative diseases, and developmental biology. By utilizing CNOT6 knockout cell lines, researchers can elucidate the downstream effects of altered mRNA regulation, providing insights that could lead to novel therapeutic targets in clinical settings.

One of the key advantages of using CNOT6 gene knockout cell lines is their reproducibility and specificity in modeling the direct effects of gene loss, allowing for the creation of more reliable data compared to alternative methods such as pharmacological inhibition. In contrast to conventional cell lines, these knockout models enable a clearer interpretation of gene function, thereby enhancing the validity of research outcomes.

For researchers and clinicians alike, the insights derived from CNOT6 knockout cell lines can lead to advancements in understanding gene regulatory networks and developing targeted therapies. Our company prides itself on its commitment to creating high-quality, precision biological products that empower the scientific community. By leveraging cutting-edge technology and a deep understanding of molecular biology, we provide researchers with the tools they need to conduct innovative research and drive progress in their respective fields.

Please note that all services are for research use only. Not intended for any clinical use.

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