Gene: CLN6
Official Full Name: CLN6 transmembrane ER proteinprovided by HGNC
Gene Summary: This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function. [provided by RefSeq, Oct 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20269 | CLN6 Knockout cell line (HeLa) | Human | CLN6 | 1:3~1:6 | Negative | Online Inquiry |
KO20270 | CLN6 Knockout cell line (HCT 116) | Human | CLN6 | 1:2~1:4 | Negative | Online Inquiry |
KO20271 | CLN6 Knockout cell line (HEK293) | Human | CLN6 | 1:3~1:6 | Negative | Online Inquiry |
KO20272 | CLN6 Knockout cell line (A549) | Human | CLN6 | 1:3~1:4 | Negative | Online Inquiry |
CLN6 Gene Knockout Cell Lines represent a pivotal tool in the field of genetic research and therapeutic development, specifically aimed at exploring the functional implications of the CLN6 gene. These cell lines have been genetically engineered to have a complete knockout of the CLN6 gene, facilitating the study of its role in cellular functions, disease progression, and potential therapeutic approaches. The underlying mechanism involves targeted gene disruption through techniques such as CRISPR/Cas9 or homologous recombination, resulting in a loss of function for CLN6, which is crucial for understanding its contributions to cellular homeostasis and pathophysiology.
The scientific importance of CLN6 Gene Knockout Cell Lines is underscored by their application in research focused on various neurodegenerative diseases, particularly Batten disease, a genetic disorder leading to severe neurological decline. These cell lines allow researchers to delve into the molecular pathways altered in the absence of CLN6, providing valuable insights that could lead to the development of targeted therapies or gene interventions.
In comparison to alternative models, such as primary neuronal cultures or animal models, CLN6 Gene Knockout Cell Lines offer several advantages. They provide a more controlled environment for experimentation, allowing for standardized conditions that enhance reproducibility. Furthermore, these cell lines are amenable to high-throughput screening, making them ideal for drug discovery and genetic studies.
For researchers and clinicians, the value of CLN6 Gene Knockout Cell Lines lies in their ability to elucidate the mechanisms underlying complex genetic conditions, pushing forward the boundaries of understanding and treatment. By integrating genetic insights with potential therapeutic developments, these cell lines contribute significantly to both basic and translational research efforts.
At [Company Name], we pride ourselves on our deep expertise in genetic engineering and cell line development, ensuring that our products, including the CLN6 Gene Knockout Cell Lines, meet the highest standards of quality and reliability to accelerate scientific breakthroughs.
Please note that all services are for research use only. Not intended for any clinical use.
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