Gene: CLK3
Official Full Name: CDC like kinase 3provided by HGNC
Gene Summary: This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05501 | CLK3 Knockout cell line (HeLa) | Human | CLK3 | 1:3~1:6 | Negative | Online Inquiry |
KO05502 | CLK3 Knockout cell line (HCT 116) | Human | CLK3 | 1:2~1:4 | Negative | Online Inquiry |
KO05503 | CLK3 Knockout cell line (HEK293) | Human | CLK3 | 1:3~1:6 | Negative | Online Inquiry |
KO05504 | CLK3 Knockout cell line (A549) | Human | CLK3 | 1:3~1:4 | Negative | Online Inquiry |
CLK3 Gene Knockout Cell Lines are genetically engineered cell models where the CLK3 gene has been specifically inactivated or "knocked out." This innovative approach allows scientists to study the role of CLK3, a critical player in RNA splicing and gene regulation, underpinned by its involvement in various cellular processes including cell cycle regulation and response to stress. By leveraging these knockout cell lines, researchers can explore the physiological and pathological implications of CLK3 deficiency, including its potential association with diseases such as cancer and neurodegenerative disorders.
The mechanism of action of CLK3 knockout cell lines primarily revolves around the disruption of normal CLK3 function, leading to altered splicing patterns and gene expression profiles. This enables comprehensive investigations into how CLK3 influences cellular behavior and identity. These cell lines serve as vital tools in elucidating the gene's contributions to both normal physiological states and disease pathways, thus advancing scientific understanding in molecular biology and translational research.
In clinical and research settings, CLK3 Gene Knockout Cell Lines are invaluable for drug discovery, biomarker development, and functional genomics. Their provision aids scientists in rapidly assessing the biological consequences of CLK3 inactivation, offering a robust framework for testing therapeutic interventions aimed at diseases linked to RNA processing anomalies.
Compared to traditional cell lines or more generalized knockout systems, CLK3 Gene Knockout Cell Lines provide specific insights into CLK3-related biological mechanisms. They are created using cutting-edge CRISPR/Cas9 technology, ensuring high efficiency and precision in gene editing. This specificity allows researchers to get transformational data, enhancing the reliability of experimental outcomes.
For researchers and clinicians focused on the genetic intricacies of cell function, these knockout cell lines are an essential addition to their toolset, promising enhanced efficiency and depth in their investigative pursuits. With a commitment to pioneering biological solutions and a robust portfolio of genomic tools, our company is dedicated to providing the highest quality products to support groundbreaking research and clinical advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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